Los Blancos regained the lead through Isco in the 62nd minute, however, before Lucas Vasquez scored a third for the visitors late on.
Read how it all unfolded in Sports Mole's minute-by-minute live commentary of the action below.
OSASUNA: Sirigu; Bonnin, Oier, Vujadinovic, Fuentes; Romero, Causic, Tienza, Berenguer; Riviere, Leon
REAL: Navas; Ramos, Varane, Nacho; Danilo, Casemiro, Modric, Isco, Marcelo; Ronaldo, Benzema
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Ramos 500th game for Madrid - 13 trophies inc 2 Champions Leagues, 3 Ligas, 2 Copas. 66 goals, 35 assists. 21 red cards, 173 yellow cards.— Dermot Corrigan (@dermotmcorrigan) February 11, 2017