Both players miss out on the trip to Andalusia, with Koke still nursing a hamstring injury which has seen him sit out the last three weeks of action, while Croatian international Mandzukic is also absent from the starting lineup.
In terms of Sevilla, who find themselves eight points behind their opponents heading into this one, they have named an attacking side with Tottenham Hotspur-linked forward Carlos Bacca being supported by Vitolo in attack.
Check out the views of the Sports Mole Sofa team as they preview the La Liga clash:
Sevilla XI: Rico; Coke, Arribas; Kolo, Navarro; Iborra, Krychowiak, Vidal, Banega, Vitolo; Bacca
Atletico Madrid XI: Moya; Juanfran, Miranda, Godin, Gamez; Gabi, Tiago, Mario; Raul Garcia, Arda; Griezmann
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