In addition, Sergio Romero replaces David de Gea in goal, Matteo Darmian and Daley Blind replace Antonio Valencia and Ashley Young in defence, and Ander Herrera, Marouane Fellaini and Jesse Lingard come into midfield.
The Red Devils, who thrashed Newcastle United 4-1 at the weekend, can seal top spot in Group A by avoiding defeat in Switzerland.
Raphael Wicky, meanwhile, has made three changes to the Basel side which thrashed Sion 5-1 at the weekend.
Basel: Vaclik; Akanji, Suchy, Balanta; Die, Zuffi, Lang, Petretta; Steffen, Elyounoussi, Oberlin
Subs: Salvi, Franzzon, Ajeti, Riveros, Manzambi, Itten, Bua
Manchester United: Romero; Darmian, Smalling, Rojo, Blind; Herrera, Fellaini; Lingard, Pogba, Martial; Lukaku
Subs: Pereira, Lindelof, Shaw, Matic, McTominay, Rashford, Ibrahimovic
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