Despite travelling with the Reds to Spain, Adam Lallana is not risked by Klopp and misses out on the matchday squad as he continues his recovery from a thigh injury.
Sevilla, meanwhile, have made three changes to the side that beat Celta Vigo on Saturday.
Sevilla: Rico; Mercado, Geis, Lenglet, Escudero; Pizarro, N'Zonzi, Banega; Sarabia, Nolito, Ben Yedder
Subs: Soria, Corchia, Krohn-Dehli, Correa, Navas, Muriel, Vazquez
Liverpool: Karius; Gomez, Klavan, Lovren, Moreno; Wijnaldum, Henderson, Coutinho; Mane, Salah, Firmino
Subs: Mignolet, Milner, Sturridge, Oxlade-Chamberlain, Can, Solanke, Alexander-Arnold
Follow all the action from the Ramon Sanchez Pizjuan with Sports Mole's live match commentary.