Moreno has previously lined up against the La Liga outfit in the 2016 Europa League final and in the 2-2 draw at Anfield in September, but the left-back will be returning to the Ramon Sanchez Pizjuan Stadium for the first time on Tuesday night.
The Spaniard has admitted that he is keen to secure the win that would take Liverpool through to the last 16, but acknowledged that it felt both "strange and beautiful" to be back in familiar surroundings.
The 25-year-old told Marca: "It is going to be strange and beautiful at the same time. All of my family and friends will be in the stands watching.
"I'm a Liverpool player though and every time I wear this jersey I want to win and I'm not concerned about anything else.
"When Sevilla plays against another team, I obviously want them to win but if we face each other, then I'm sorry but I want the three points."