A win for Brian Smith's side in front of their own supporters this weekend could lift them up to ninth place in the table.
The visitors will be looking to restore some pride after their relegation from the top flight was confirmed last weekend with a defeat to Northampton Saints.
Irish: Homer, Yarde, Armitage, Shingler, Tagicakibau, Humphreys, Allinson, Hala'ufia, Treviranus, Garvey, Evans, Skivington, Aulika, Paice, Corbisiero
Replacements: Lawson, Yanuyanutawa, Halavatau, Low, Danaher, Ojo, Geraghty, Moates
Welsh: Arscott, Scott, Stegmann, Parker, Caprice, Ross, Keats, Browne, Hills, Cabello Farias, Kulemin, Corker, Ion, Bateman, Bristow
Replacements: George, Joly, Tideswell, Brown, Balding, Lewis, Davies, Ajuwa
Sports Mole says: Irish to heap misery on Welsh