While fourth-placed Newcastle will be looking to take a step closer towards Champions League football, Wigan can edge further away from the relegation zone with a win against the high-flying Magpies.
Roberto Martinez is expected to have Franco Di Santo fit for the clash after the striker picked up a calf injury in last weekend's defeat at Fulham.
However, Hugo Rodallega remains a doubt with the ankle problem that he sustained in March.
Newcastle boss Alan Pardew is thought to have no new injury concerns ahead of the match, with in-form striker Papiss Cisse almost guaranteed to start in attack with fellow Senegal international Demba Ba.
Wigan: Al Habsi; Alcaraz, Caldwell, Boyce, Figueroa; McCarthy, Moses, Gomez, McArthur, Beausejour; Di Santo
Newcastle: Krul; Coloccini, Santon, Simpson, Williamson; Cabaye, Ben Arfa, Gutierrez, Tiote; Cisse, Ba
Sports Mole says: 0-2