The German outfit will start the former Manchester United striker up front on his own, with Hakan Calhanoglu sat just behind supporting the Mexican.
Nikolay Signevich will lead the attack for the Belarusian side.
Bayer Leverkusen: Leno; Hilbert, Tah, Papadopoulos, Wendell; Bender, Kampl, Bellarabi, Mehmedi; Calhanoglu, Hernandez
Subs: Kresic, Ramalho, Kiebling, Boenisch, Brandt, Kramer, Donati
BATE Borisov: Chernik; Palyakow, Dubra, Milunovic, Mladenovic; Baga, Aleksiyevich, Stasevich, Hleb, Gordeychuk; Signevich
Subs: Karnitskiy, Volodko, Nikolic, Jevtic, Rios, Soroko, Volodko
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