Managerless Barnsley currently prop up the table but could move off the bottom and to within one point of safety with a win at the weekend.
The hosts have struggled of late, winning just one of their last seven matches, although they were unlucky to come away with nothing from last weekend's match against leaders Burnley.
The Tykes have the joint-worst defensive record in the division and are one of just four teams to have averaged under one goal scored per game this season, leaving interim manager Micky Mellon with an uphill battle to turn their season around.
Yeovil, meanwhile, have experienced an upturn in fortunes in recent weeks, sparked by their shock 3-0 victory away to Watford at the end of last month.
The Glovers have won two and drawn one of their last three matches and could move out of the bottom three if they extended their unbeaten run to four games with a win.
Possible starting lineups
Barnsley: Butland; Kennedy, Ramage, Crainey, Wiseman; O'Brien, Perkins, Mellis, Cywka, McCourt; Tudgay
Yeovil: Dunn; Ayling, Duffy, Webster, Davis; Grant, Upson, Lundstram, Edwards; Morgan, Miller
Sports Mole says: 1-1