The hosts have no fresh injury concerns ahead of the match and will expect Huntelaar, Afellay and Jefferson Farfan to lead their attack.
Vito Mannone should start in goal for Arsenal as Wojciech Szczesny remains sidelined through injury. Jack Wilshere should also keep his place in the side following his recent return from injury and Theo Walcott may be handed a place in the team.
Schalke: Unnerstall; Uchida, Howedes, Matip, Fuchs; Neustadter, Jones; Holtby, Afellay; Farfan, Huntelaar
Arsenal: Mannone; Sagna, Mertesacker, Vermaelen, Santos; Cazorla, Arteta, Wilshere, Walcott; Podolski, Giroud
Sports Mole says: 2-0