La Liga resumes at the weekend following the international break, with Malaga travelling to Madrid in the early kickoff on Saturday.
"It's not an impossible task and we can beat anyone. Every team can lose because La Liga is very competitive, with many quality players," Tissone told the club's official website.
"At any one time you could have a good shot and that might make the difference. We must do a good job defensively and play well when we are on the counter-attack, which is one of our weapons."