That triumph was inspired by an 11-minute hat-trick from Nick Powell, who again has to make do with a spot on the bench this afternoon as he is eased back into action.
In terms of the home side, boss Chris Hughton has also made a couple of alterations for what could be a historic afternoon for the Seagulls, knowing that promotion to the Premier League can be secured later today.
Steve Sidwell and Sebastian Pocognoli fail to make the 18-man squad, meanwhile, as Albion look for three more points that will put them on the brink of ending their 34-year wait for top-flight football.
Brighton & Hove Albion: Stockdale; Bruno, Hunemeier, Dunk, Bong; March, Kayal, Stephens, Knockaert; Hemed, Murray
Subs: Maenpaa, Norwood, Akpom, Murphy, Tomori, Rosenior, Skalak
Wigan Athletic: Haugaard; Hanson, Buxton, Burn, Warnock; Perkins, MacDonald, Power, Tunnicliffe, Jacobs; Obertan
Subs: Gilks, Morgan, Morsy, Powell, Byrne, Colclough, Connolly