The Argentine comes into the side for Andres Iniesta, who picked up an injury during Wedneday's Copa del Rey quarter-final triumph over Real Madrid.
Victor Valdes also returns in goal for the champions following Jose Pinto's spell in the side.
Elsewhere, Adriano has been chosen to join Lionel Messi in attack.
Rodriguez; Rodriguez, Oriol, Musacchio, Angel; Cani, Senna, Iglesias, Llido; Ruben, Barroso
Subs: Cesar, Marchena, Zapata, Gaspar, Guzman, Castellani, Camunas
Valdes; Alves, Pique, Puyol, Abidal; Mascherano, Xavi, Fabregas, Busquets; Messi, Adriano
Subs: Pinto, Alexis, Thiago, Cuenca, Sergi Roberto, Tello, Dos Santos
Villarreal team news to follow.