Alvaro Odriozola has been selected at right-back for cap number two, meanwhile, with Marc Batra being overlooked, while further forward Alvaro Morata has overcome a minor toe injury to feature from the off.
In terms of the visitors, who will join La Roja in next year's World Cup finals, they have called on Danny Carvajal in goal - and not the more experienced Patrick Pemberton - due to the injury absence of Keylor Navas.
San Jose Earthquakes ace Marco Urena leads the line, meanwhile, aiming to improve on a run that has seen him net six goals in 31 outings for club and country this term.
Spain: Kepa; Odriozola, Pique, Ramos, Jordi Alba; Busquets, Iniesta, Thiago; Silva, Morata, Isco
Costa Rica: Carvajal; Gamboa, Waston, Oscar Duarte, Calvo, Oviedo; Bolanos, Borges, Tejeda, Venegas; Urena
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