It is likely that the Arsenal legend will feature for the North London side, but may have to be resigned to the bench while Robin van Persie takes the lone striker role up front.
Ignasi Miquel is expected to replace Francis Coquelin after the defender picked up an injury at the Emirates against Leeds, while Johan Djourou should return from his match ban, which will be welcomed by boss Arsene Wenger, who is suffering from a number of defensive casualties.
Despite Andrey Arshavin being out of form for the Gunners, he is expected to start in Wales following the departure of Gervinho to the African Cup of Nations.
Goalkeeper Michel Vorm should come into the team along with Scott Sinclair and Joe Allen, while proposed loan signing Josh McEachran will likely have to wait for his Swans debut as the deal from Chelsea has yet to be completed.
Swansea: Vorm; Williams, Taylor, Caulker, Rangel; Sinclair, Dyer, Allen, Routledge, Gower, Britton; Graham
Arsenal: Szeczesny; Miquel, Mertesacker, Koscielny, Djourou; Song; Walcott, Arteta, Ramsey, Arshavin; Van Persie
Sports Mole says: 1-2