Liga MX 2021-22 Head-to-Head
Top Six
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Atlas | 14 | 6 | 5 | 3 | 16 | 9 | 7 | 23 |
| 2 | MazatlanMazatlan | 10 | 4 | 4 | 2 | 15 | 11 | 4 | 16 |
| 3 | PumasPumas | 12 | 4 | 4 | 4 | 9 | 11 | -2 | 16 |
| 4 | Atletico San Luis | 10 | 4 | 2 | 4 | 13 | 13 | 0 | 14 |
| 5 | MonterreyMonterrey | 12 | 3 | 5 | 4 | 12 | 13 | -1 | 14 |
| 6 | Juarez | 10 | 3 | 0 | 7 | 7 | 15 | -8 | 9 |
Bottom Six
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Cruz AzulCruz Azul | 9 | 7 | 1 | 1 | 18 | 5 | 13 | 22 |
| 2 | Club AmericaAmerica | 9 | 5 | 2 | 2 | 16 | 10 | 6 | 17 |
| 3 | Santos LagunaSantos Laguna | 10 | 3 | 3 | 4 | 18 | 17 | 1 | 12 |
| 4 | TolucaToluca | 10 | 3 | 3 | 4 | 14 | 19 | -5 | 12 |
| 5 | Club TijuanaTijuana | 10 | 2 | 2 | 6 | 8 | 19 | -11 | 8 |
| 6 | QueretaroQueretaro | 10 | 0 | 7 | 3 | 9 | 13 | -4 | 7 |
