The Argentine is joined up front by Magaye Gueye, while on-loan Landon Donovan begins in midfield.
Fulham have Bryan Ruiz and Andy Johnson in attack, with Clint Dempsey, who scored a hat-trick against Newcastle United on Saturday, sitting behind the pairing in midfield.
Howard; Neville, Duffy, Heitinga, Baines; Gibson, Fellaini, Donovan, Cahill; Gueye, Stracqualursi
Subs: Hahnemann, Hibbert, Baxter, Vellios, Drenthe, Saha, Anichebe
Stockdale; Kelly, Hangeland, Hughes, Riise; Dempsey, Baird, Murphy, Duff; Ruiz, Johnson
Subs: Etheridge, Sidwell, Senderos, Frei, Zamora, Davies, Trotta