Senderos, who spent the second half of the 2009-10 season on loan at Goodison Park, knows that Everton have the strength to make it difficult for Martin Jol's side to progress from the fourth round.
However, the centre-back is eager to help his side over another former club after beating Arsenal earlier this month.
"It is a tough draw for us," he told the club's official website. "[Everton] are a decent side and they have players with a lot of quality. Having spent a brief period with them two years ago, I know a bit about them.
"The FA Cup is an amazing competition and it's one that players and fans love to be part of. I've been lucky enough to be part of a team that not only reached the final, but won it too. That was a moment I will never forget.
"I can see no reason why we can't put a decent run together. We're out of Europe now, so it's a good chance for us to make up for that."
Meanwhile, Fulham host former boss Roy Hodgson in the Premier League in six days time.