Having broken new ground at Roland Garros, Tsitsipas is competing in his first major final, building on last year's appearance in the last four.
On the back of defeating Rafael Nadal in the latest chapter of their storied rivalry, Djokovic was quick to claim that it required one of his all-time best performances to overcome the greatest clay-court player of all time.
Djokovic fully deserved the praise and adulation which followed, but the legendary Serbian must now refocus if he wants to add a second Roland Garros crown to his collection.
Much attention has been placed on the energy used by Djokovic in dispatching Nadal, but Tsitsipas has also not had things go his own way during his two weeks in the French capital.
Becoming the first Greek player to reach a Grand Slam, a level of pressure has been placed on the shoulders of a 22-year-old who surely still has his best tennis days ahead of them.
Nevertheless, with Djokovic looking to cement a legacy and become regarded as the greatest player of all time, Tsitsipas has the freedom to swing from the hips and write his own piece of history.
Head To Head
The majority of players go through their career without ever toppling Djokovic, but Tsitsipas already has two wins to his name since their first meeting in 2018.
More impressively, Tsitsipas went 2-1 ahead in their head-to-head, backing up his previous success in Canada with another three-set triumph in Shanghai.
However, each of those wins came on hard courts, and Djokovic has put together a four-match streak in his favour since the back end of 2019.
Their last two meetings, on the clay in Paris and Rome, have each gone the distance, but Djokovic was able to deal with adversity on both occasions to outlast his opponent.
We say: Djokovic to win in four sets
Having naturally taken pleasure in watching Djokovic go to great lengths against Nadal, Tsitsipas will feel that he could capitalise on any lingering fatigue in his opponent. However, it would take a brave person to back against Djokovic not winning this contest, and we expect the Serbian to prevail in four sets.