The Dutch frontman has been selected alongside Wayne Rooney for the Gunners' visit to Old Trafford this afternoon.
Antonio Valencia and Ashley Young line up on the wings for United, with Michael Carrick and Tom Cleverley in the heart of midfield.
Jack Wilshere also starts a second game in a row for Arsenal following his long absence from the game.
Man Utd: De Gea; Rafael, Evra, Ferdinand, Evans; Valencia, Carrick, Cleverley, Young; Rooney, Van Persie
Arsenal: Mannone; Sagna, Mertesacker, Vermaelen, Santos; Arteta, Wilshere, Ramsey; Cazorla; Podolski, Giroud