Armenia vs. Liechtenstein (Wednesday, 5.00pm)
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Armenia play host to Liechtenstein at the Vazgen Sargsyan Republican Stadium on Wednesday seeking an immediate response to a huge defeat last time out.
On the other hand, Liechtenstein have neither picked up a win nor a point after the first five round of matches and have it all to do in World Cup 2022 Qualifying Group J.
We say: Armenia 4-1 Liechtenstein
Armenia, in search of a positive response to last week's defeat, are favourites to claim all three points in this one against a side struggling at both ends of the field. We expect the home to come out on top, scoring plenty of goals en route to a comfortable victory.
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Italy vs. Lithuania (Wednesday, 7.45pm)
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Italy look to recover from their post-Euros hangover on Wednesday, as they welcome winless Lithuania to Sassuolo in World Cup Qualifying Group C.
While the Azzurri have recorded disappointing draws in the first two matches of this month's qualification triple-header, they remain clear at the top of the group and are well down the track towards Qatar 2022.
We say: Italy 2-0 Lithuania
Having started their campaign with three successive 2-0 wins, Italy can get back on track this week with a similar result, even if they choose to rest some weary legs, as Mancini has intimated.
The next generation of Azzurri attackers may have an opportunity to shine against a lowly Lithuanian side ready for the taking, and are poised to make their mark.
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> How Italy could line up against Lithuania
N. Ireland vs. Switzerland (Wednesday, 7.45pm)
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Northern Ireland return to competitive action on Wednesday evening knowing that they realistically must avoid defeat against Switzerland to retain any hope of qualifying for the next World Cup.
While the visitors will still be targeting top spot in Group C, victory will be enough to put them on the brink of guaranteeing at least a playoff spot.
We say: Northern Ireland 0-2 Switzerland
While Baraclough and his players are currently on a high, facing Switzerland represents a significant step up in class for Northern Ireland. With that in mind, we expect the visitors to battle their way to all three points, keeping a clean sheet in the process.
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Belarus vs. Belgium (Wednesday, 7.45pm)
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Having come so close yet so far against Wales, Belarus prepare for another tough examination in World Cup 2022 qualifying against Group E against leaders Belgium on Wednesday night.
The hosts fell to a last-gasp 3-2 defeat against the Welsh Dragons last time out, whereas Belgium cruised to a 3-0 victory over the Czech Republic.
We say: Belarus 1-4 Belgium
Belgium manager Martinez ought to shuffle the pack for this final fixture of the international break as he works around jelly legs, and another 8-0 thrashing is surely off the cards here.
The hosts performed valiantly against Wales even if their efforts did count for nought, but Belgium have swept aside almost everything before them in qualifying during the past 10 years and should cement their place at the summit with another routine success.
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Wales vs. Estonia (Wednesday, 7.45pm)
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After surviving a huge scare against Belarus at the weekend, Wales will be aiming to make it three wins in a row in World Cup qualifying when they host Estonia on Wednesday.
The Dragons are third in Group E, a point behind second-placed Czech Republic with a game in hand, while Estonia are bottom and without a point from their opening three matches.
We say: Wales 3-0 Estonia
Wales have lost just one of their last 16 home qualifying matches for the Euros and World Cup, while Estonia have won one of their last 18 away qualifiers for major tournaments.
The Dragons are not at full strength, while their defence is nowhere near as strong as it once was, but this is a game you would expect the hosts to comfortably win.
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Greece vs. Sweden (Wednesday, 7.45pm)
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Sweden head into their World Cup qualifier with Greece knowing that another three points will keep them in charge of Group B.
However, the home side, currently sitting six points adrift of their next opponents, will come back into contention with victory in Athens.
We say: Greece 1-2 Sweden
Given the opportunity that is front of them, we do not expect Sweden to have it all their own way over the coming months. Nevertheless, we are predicting a hard-fought victory for the visitors against opponents who have struggled for wins of late.
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Kosovo vs. Spain (Wednesday, 7.45pm)
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Spain will look to build on a dominant 4-0 win over Georgia when they return to World Cup Qualifying action on Wednesday, with a trip to take on Kosovo.
La Roja bounced back in style after a defeat to Sweden and will look to round off the international break with another three-point haul, while their hosts will aim to extend their unbeaten run to three games in qualifying.
We say: Kosovo 0-3 Spain
Despite Kosovo improving in the latest round of international games, we do not see them having enough to topple La Roja on Wednesday.
Enrique still has a strong squad at his disposal, and they will be keen to impress again with a dominant win as they look to stay ahead of Sweden.
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> How Spain could line up against Kosovo
Albania vs. San Marino (Wednesday, 7.45pm)
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After picking up a crucial three points against Hungary on Sunday, Albania will be looking to keep the pressure on the two top places in Group I of the World Cup 2022 qualification.
They will face San Marino on Wednesday, who currently sit at the foot of the table having yet to register a single point within the competition.
We say: Albania 5-0 San Marino
Anything other than a victory for Albania would be a huge surprise from this fixture, with three points being expected from Reja's squad here.
Considering San Marino's history, it is going to be a game where the hosts will be looking to score as many as possible in case goal difference proves to be vital.
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Hungary vs. Andorra (Wednesday, 7.45pm)
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Hungary welcome Andorra to the Ferenc Puskas Stadium on Wednesday evening for the final World Cup 2022 qualifier of this international break.
The sides sit fourth and fifth in Group I, but the hosts are fighting for the second qualification spot with Poland and Albania, whilst Andorra have only San Marino for company at the bottom of the group.
We say: Hungary 2-0 Andorra
Hungary's recent blip should be just that on what has been a steady show of improvement in recent times, and they will surely have enough to comfortably see off Andorra.
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Poland vs. England (Wednesday, 7.45pm)
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Arguably England's toughest test of World Cup 2022 qualifying takes place in Warsaw on Wednesday evening, as the Three Lions prepare for battle with Poland in Group I.
Gareth Southgate's second-string XI cruised to a 4-0 win over Andorra last time out, while Poland put seven past San Marino in a 7-1 thrashing on Sunday night.
We say: Poland 1-3 England
Poland managed to find a way past England's often impenetrable rearguard in the absence of Lewandowski last time out, and the Bayern Munich man ought to feel confident about his chances of making the net ripple alongside weekend hat-trick hero Buksa.
However, all of England's big-hitters are well-rested, and the Three Lions can all but guarantee a first-placed finish in the group with a victory here, and we are backing Southgate's men to do just that, albeit without a clean sheet.
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> How England could line up against Poland
Iceland vs. Germany (Wednesday, 7.45pm)
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Hansi Flick will look to continue his perfect start to life as Germany manager on Wednesday, when they travel to take on Iceland in the final game of this round of World Cup Qualifying fixtures.
The two nations met in the opening game of this qualification campaign, with Wednesday's visitors picking up a 3-0 victory, and they have largely dominated the group throughout.
We say: Iceland 0-3 Germany
Flick has an abundance of quality options all over the pitch in this Germany side, and we see them continuing to build momentum under the new boss with another convincing victory on Wednesday.
Die Mannschaft have looked strong at both ends since their departure from Euro 2020, and with every player keen to impress and earn the favour of the new manager, we expect another eye-catching team showing.
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> How Germany could line up against Iceland
N. Macedonia vs. Romania (Wednesday, 7.45pm)
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North Macedonia will host Romania on Wednesday as the World Cup 2022 qualification competition continues for Group J, which has proven to be one of the most closely contested to this point.
The visitors sit just one point ahead of the Lions with both teams heading into the game having been unbeaten in their previous two matches.
We say: North Macedonia 0-1 Romania
This is an important game for both teams due to how tight Group J is right now, and each have had an impressive couple of performances during this international break.
However, Romania have managed to pick up crucial victories in comparison to the draws North Macedonia have earned, and that added momentum should see them make it a trio of wins.
