Ozil misses out through injury, and Iwobi replaces the German as Alexis Sanchez's attacking midfield partner.
Elsewhere, Arsene Wenger names the same team that defeated Tottenham Hotspur 2-0 at the Emirates Stadium, as a back three of Shkodran Mustafi, Nacho Monreal and Laurent Koscielny is supported by Hector Bellerin and Sead Kolasinac at wing-back.
Burnley: Pope; Lowton, Tarkowski, Mee, Ward; Gudmundsson, Cork, Hendrick, Defour, Brady; Barnes
Subs: Wood, Vokes, Westwood, Long, Arfield, Bardsley, Lindegaard
Arsenal: Cech; Kościelny, Mustafi, Monreal; Bellerin, Ramsey, Xhaka, Kolasinac; Iwobi, Sanchez; Lacazette
Subs: Ospina, Mertesacker, Coquelin, Wilshere, Maitland-Niles, Welbeck, Giroud
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