The Tykes haven't enjoyed the best of starts to the season, but they will be impressed with the form of striker Chris O'Grady, who has netted seven times this season.
Sheffield Wednesday have yet to win in the Championship this season, although they have only lost on four occasions.
Sheffield Wednesday: LLDDD
Possible starting lineups
Barnsley: McCarthy; Butland; Wiseman, Kennedy, Fox, Cranie; Mvoto, Mellis, Perkins, O'Brien; O'Grady, Pedersen
Sheffield Wednesday: Kirkland; Buxton, Reda Johnson, Zayatte, R.Johnson; J.Johnson, Antonio, Coke, McPhail, Helan; Fryatt
Sports Mole says: 2-1