Greek Superleague 2021-22 Head-to-Head
Top Six
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | OlympiacosOlympiacos | 9 | 6 | 3 | 0 | 13 | 5 | 8 | 21 |
| 2 | PAOKPAOK | 10 | 5 | 3 | 2 | 16 | 8 | 8 | 18 |
| 3 | Aris ThessalonikiAris | 9 | 3 | 3 | 3 | 6 | 7 | -1 | 12 |
| 4 | OFI CreteOFI Crete | 10 | 2 | 4 | 4 | 11 | 18 | -7 | 10 |
| 5 | PanathinaikosPanathinaikos | 10 | 2 | 3 | 5 | 9 | 10 | -1 | 9 |
| 6 | AEK AthensAEK Athens | 10 | 2 | 2 | 6 | 11 | 18 | -7 | 8 |
Bottom Six
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | PAS GianninaPAS Giannina | 10 | 6 | 2 | 2 | 10 | 4 | 6 | 20 |
| 2 | Asteras TripolisAsteras | 10 | 5 | 3 | 2 | 11 | 6 | 5 | 18 |
| 3 | LamiaLamia | 10 | 3 | 2 | 5 | 8 | 11 | -3 | 11 |
| 4 | Ionikos | 9 | 2 | 4 | 3 | 12 | 10 | 2 | 10 |
| 5 | PanetolikosPanetolikos | 9 | 2 | 4 | 3 | 6 | 9 | -3 | 10 |
| 6 | Apollon SmyrniApollon | 10 | 2 | 3 | 5 | 3 | 10 | -7 | 9 |
