The Vicarage Road side are just one point behind Quins, and have had only one defeat in their last eight games in the Premiership.
Meanwhile, Sale will be looking to build on their 33-27 win over Worcester Warriors last weekend and climb off the bottom of the table.
Sharks have just two wins this season, but are now only one point behind London Irish, who face a tricky tie this afternoon.
Saracens: Wyles, Short, Tomkins, Barritt, Strettle, Farrell, Wigglesworth, Joubert, Fraser, Brown, Kruis, Borthwick, Stevens, Brits, Lunipola.
Sale: Miller, Brady, Leota, Tuitupou, Cueto, Cipriani, Peel, Powell, Vernon, Gaskell, Myall, Gray, Buckley, Jones, Harrison.
Sports Mole says: Comfortable win for Saracens