Pep Guardiola's side were 11 points behind their bitter rivals earlier in the season, but 11 successive wins have put them right back in contention.
However, a first triumph at the Nou Camp for Jose Mourinho would open up a seven-point gap for his team with just four games remaining.
Alexis Sanchez could feature for the hosts, despite suffering from a minor knock, while Gerard Pique is expected to return in defence.
Madrid should have Marcelo at their disposal, with Xabi Alonso also coming back from a one-match domestic suspension.
Real Madrid: DWWDWW
Barcelona: Valdes; Alves, Pique, Adriano; Busquets, Xavi, Iniesta, Fabregas; Sanchez, Messi
Real Madrid: Casillas; Marcelo, Pepe, Coentrao, Ramos; Xabi Alonso, Khedira, Ozil, Di Maria; Ronaldo; Benzema
Sports Mole says: 2-1