With a trip to Real Madrid coming up in the last 16 of the Champions League on Wednesday evening, many had expected manager Sir Alex Ferguson to rest the duo, who have scored 35 club goals between them this season.
Man United: De Gea; Rafael, Evra, Vidic, Evans; Jones, Cleverley, Valencia, Giggs; Rooney, Van Persie
Subs: Amos, Anderson, Smalling, Hernandez, Carrick, Nani, Welbeck
Everton: Howard; Jagielka, Baines, Neville, Distin; Gibson, Mirallas, Pienaar, Osman, Fellaini; Anichebe
Subs: Mucha, Heitinga, Jelavic, Oviedo, Naismith, Hitzlsperger, Stones