Madrid opened the scoring in the Bernabeu, but failed to hold out against their greatest rivals before falling to a 2-1 defeat.
All of which makes Barca favourites ahead of the second leg meeting on Wednesday evening.
Both managers named strong starting lineups for last week's El Clasico and the same is expected this time around.
Real Madrid: WWWWLW
Barcelona: Pinto; Adriano, Pique, Puyol, Alves; Busquets, Xavi, Iniesta, Fabregas; Sanchez; Messi.
Real Madrid: Casillas; Marcelo, Pepe, Carvalho, Ramos; Ozil, Alonso, Diarra, Kaka; Ronaldo; Benzema.
Sports Mole says: 2-1