The top two from the last two seasons face off in the headline fixture of gameweek eight as Manchester City welcome leaders and champions Liverpool to the Etihad Stadium.
The Reds could be knocked off top spot before that, though, with a clutch of teams - including in-form Southampton, Leicester City and Tottenham Hotspur - in action before them.
There is also an intriguing contest between high-flying Everton and out-of-form Manchester United, while Burnley, Sheffield United and West Bromwich Albion will all once again attempt to pick up their first win of the season.
Click play below to watch or listen to Sports Mole's predictions for all 10 matches courtesy of Editor Barney Corkhill and Football Editor Matt Law.
Watch the full discussion here:
Or you can listen to the full podcast here:
FRIDAY
5.30pm - Brighton & Hove Albion vs. Burnley (0:29)
8pm - Southampton vs. Newcastle United (2:47)
SATURDAY
12.30pm - Everton vs. Manchester United (5:03)
3pm - Crystal Palace vs. Leeds United (9:19)
5.30pm - Chelsea vs. Sheffield United (11:24)
8pm - West Ham United vs. Fulham (14:39)
SUNDAY
12pm - West Bromwich Albion vs. Tottenham Hotspur (17:51)
2pm - Leicester City vs. Wolverhampton Wanderers (21:47)
4.30pm - Manchester City vs. Liverpool (24:24)
7.15pm - Arsenal vs. Aston Villa (27:32)
