| | First Half starts. |
| 2' | | Penalty Napoli. André-Frank Zambo Anguissa draws a foul in the penalty area. |
| 2' | | Penalty conceded by Nicola Murru - Sampdoria - after a foul in the penalty area. |
| 3' | | Delay in match - injury André-Frank Zambo Anguissa - Napoli |
| 4' | | Delay over. They are ready to continue. |
| 4' | | VAR Decision: Penalty Napoli. |
| 5' | | Delay over. They are ready to continue. |
| 5' | | Nicola Murru - Sampdoria - receive yellow card for a foul. |
| 7' | | Penalty saved! Matteo Politano - Napoli - fails to capitalise on this great opportunity, shot with left foot saved in the right corner. |
| 7' | | Corner - Napoli. Conceded by Emil Audero. |
| 7' | | Shot blocked. Victor Osimhen - Napoli - shot with the head from the centre of the box is blocked. Assist - Matteo Politano with a cross. |
| 8' | | Fouled by Victor Osimhen - Napoli |
| 8' | | Tommaso Augello - Sampdoria - won a free kick on the left wing. |
| 9' | | Missed chance. Sam Lammers - Sampdoria - shot with right foot from the centre of the box is close, but missed to the left. Assist - Valerio Verre. |
| 10' | | New attacking attempt. Manolo Gabbiadini - Sampdoria - shot with right foot from outside the box is saved in the left corner. Assist - Tommaso Augello. |
| 12' | | Fouled by Ronaldo Vieira - Sampdoria |
| 12' | | Stanislav Lobotka - Napoli - won a free kick in attack. |
| 13' | | New attacking attempt. Eljif Elmas - Napoli - shot with right foot from the left side of the box is saved by goalkeeper in the centre of the goal. Assist - Mário Rui. |
| 13' | | Fouled by André-Frank Zambo Anguissa - Napoli |
| 13' | | Tomás Rincón - Sampdoria - won a free kick in defence. |
| 14' | | New attacking attempt. Valerio Verre - Sampdoria - shot with left foot from outside the box is saved in the top right corner. Assist - Sam Lammers. |
| 14' | | Corner - Sampdoria. Conceded by Alex Meret. |
| 15' | | Missed chance. Bram Nuytinck - Sampdoria - shot with the head from the centre of the box missed to the left. Assist - Manolo Gabbiadini with a cross after corner. |
| 15' | | Hand ball by Tomás Rincón - Sampdoria |
| 17' | | New attacking attempt. Victor Osimhen - Napoli - shot with the head from the centre of the box is saved in the top centre of the goal. Assist - Giovanni Di Lorenzo with a cross. |
| 17' | | Corner - Napoli. Conceded by Emil Audero. |
| 18' | | Missed chance. Eljif Elmas - Napoli - shot with right foot from the left side of the box missed after corner. |
| 19' | | Fouled by Stanislav Lobotka - Napoli |
| 19' | | Valerio Verre - Sampdoria - won a free kick in defence. |
| 20' | | Goal! Sampdoria 0, Napoli 1. Victor Osimhen - Napoli - shot with right foot from the centre of the box to the top left corner. Assist - Mário Rui with a cross. |
| 22' | | New attacking attempt. Khvicha Kvaratskhelia - Napoli - shot with right foot from the centre of the box is saved by goalkeeper in the centre of the goal. Assist - Matteo Politano with a through ball. |
| 23' | | Missed chance. André-Frank Zambo Anguissa - Napoli - shot with right foot from outside the box is close, but missed. |
| 25' | | Fouled by Valerio Verre - Sampdoria |
| 25' | | Mário Rui - Napoli - won a free kick on the left wing. |
| 25' | | Missed chance. Sam Lammers - Sampdoria - shot with right foot from outside the box is very close to the goal. Assist - Tommaso Augello. |
| 28' | | Shot blocked. Ronaldo Vieira - Sampdoria - shot with right foot from outside the box is blocked. Assist - Mehdi Léris. |
| 30' | | Fouled by Mário Rui - Napoli |
| 30' | | Mehdi Léris - Sampdoria - won a free kick on the right wing. |
| 31' | | Fouled by Sam Lammers - Sampdoria |
| 31' | | Kim Min-Jae - Napoli - won a free kick in defence. |
| 31' | | André-Frank Zambo Anguissa - Napoli - won a free kick in defence. |
| 31' | | Fouled by Tomás Rincón - Sampdoria |
| 32' | | Missed chance. Khvicha Kvaratskhelia - Napoli - shot with right foot from the left side of the box is high and wide to the right. Assist - Mário Rui. |
| 33' | | Fouled by Juan Jesus - Napoli |
| 33' | | Manolo Gabbiadini - Sampdoria - won a free kick in attack. |
| 34' | | Missed chance. Manolo Gabbiadini - Sampdoria - shot with left foot from outside the box missed. Assist - Valerio Verre. |
| 35' | | Shot blocked. Eljif Elmas - Napoli - shot with right foot from the centre of the box is blocked. Assist - Matteo Politano. |
| 35' | | Shot blocked. Victor Osimhen - Napoli - shot with left foot from the centre of the box is blocked. Assist - Eljif Elmas. |
| 38' | | Fouled by Eljif Elmas - Napoli |
| 38' | | Manolo Gabbiadini - Sampdoria - won a free kick in defence. |
| 39' | | Fouled by Tomás Rincón - Sampdoria |
| 39' | | Victor Osimhen - Napoli - won a free kick on the right wing. |
| 39' | | Tomás Rincón - Sampdoria - receive red card. |
| 43' | | Fouled by Eljif Elmas - Napoli |
| 43' | | Manolo Gabbiadini - Sampdoria - won a free kick in defence. |
| 44' | | Fouled by Jeison Murillo - Sampdoria |
| 44' | | Khvicha Kvaratskhelia - Napoli - won a free kick in defence. |
| 45' | | Jeison Murillo - Sampdoria - receive yellow card for a foul. |
| 45+2' | | Corner - Sampdoria. Conceded by Kim Min-Jae. |
| 45+2' | | Missed chance. Khvicha Kvaratskhelia - Napoli - shot with left foot from a diffucult position on the left missed. Assist - Matteo Politano with a cross following a fast break. |
| 45+4' | | Offside - Napoli. Matteo Politano with a pass, however Giovanni Di Lorenzo is in offside. |
| 45+6' | | Offside - Napoli. Khvicha Kvaratskhelia with a pass, however Eljif Elmas is in offside. |
| 45+7' | | First Half ended - Sampdoria 0, Napoli 1. |
| 45' | | Second Half starts Sampdoria 0, Napoli 1. |
| 45' | | Substitution - Napoli. Amir Rrahmani for Kim Min-Jae. |
| 45' | | Substitution - Sampdoria. Alessandro Zanoli for Jeison Murillo. |
| 45' | | Substitution - Sampdoria. Filip Djuricic for Manolo Gabbiadini. |
| 49' | | Offside - Napoli. Giovanni Di Lorenzo with a pass, however Victor Osimhen is in offside. |
| 51' | | Corner - Napoli. Conceded by Bram Nuytinck. |
| 52' | | Shot blocked. Matteo Politano - Napoli - shot with left foot from the right side of the box is blocked. Assist - Giovanni Di Lorenzo. |
| 52' | | Corner - Napoli. Conceded by Filip Djuricic. |
| 52' | | Missed chance. Giovanni Di Lorenzo - Napoli - shot with the head from the right side of the six yard box is close, but misses the top right corner. Assist - Matteo Politano with a cross after corner. |
| 53' | | Fouled by Juan Jesus - Napoli |
| 53' | | Mehdi Léris - Sampdoria - won a free kick on the right wing. |
| 53' | | Juan Jesus - Napoli - receive yellow card for a foul. |
| 54' | | Substitution - Sampdoria. Gonzalo Villar for Valerio Verre. |
| 56' | | Shot blocked. Matteo Politano - Napoli - shot with left foot from outside the box is blocked. Assist - André-Frank Zambo Anguissa. |
| 56' | | Offside - Napoli. Matteo Politano with a pass, however Victor Osimhen is in offside. |
| 58' | | André-Frank Zambo Anguissa - Napoli - won a free kick in attack. |
| 58' | | Fouled by Ronaldo Vieira - Sampdoria |
| 59' | | Missed chance. Mário Rui - Napoli - shot with left foot from the left side of the box is high and wide to the left. |
| 60' | | Fouled by André-Frank Zambo Anguissa - Napoli |
| 60' | | Gonzalo Villar - Sampdoria - won a free kick in defence. |
| 60' | | André-Frank Zambo Anguissa - Napoli - receive yellow card for a foul. |
| 63' | | Substitution - Napoli. Hirving Lozano for Matteo Politano. |
| 63' | | Substitution - Napoli. Piotr Zielinski for Khvicha Kvaratskhelia. |
| 63' | | Shot blocked. Sam Lammers - Sampdoria - shot with left foot from the left side of the box is blocked. |
| 64' | | Shot blocked. Filip Djuricic - Sampdoria - shot with right foot from outside the box is blocked. Assist - Tommaso Augello. |
| 65' | | Missed chance. Stanislav Lobotka - Napoli - shot with right foot from outside the box is close, but missed to the left. |
| 66' | | Substitution - Napoli. Tanguy Ndombélé for André-Frank Zambo Anguissa. |
| 67' | | Fouled by Ronaldo Vieira - Sampdoria |
| 67' | | Piotr Zielinski - Napoli - won a free kick in defence. |
| 68' | | New attacking attempt. Stanislav Lobotka - Napoli - shot with right foot from outside the box is saved in the top right corner. Assist - Victor Osimhen. |
| 70' | | New attacking attempt. Hirving Lozano - Napoli - shot with left foot from outside the box is saved by goalkeeper in the centre of the goal. Assist - Tanguy Ndombélé. |
| 70' | | Fouled by Mehdi Léris - Sampdoria |
| 70' | | Mário Rui - Napoli - won a free kick in defence. |
| 72' | | Fouled by Mehdi Léris - Sampdoria |
| 72' | | Mário Rui - Napoli - won a free kick on the left wing. |
| 72' | | Mehdi Léris - Sampdoria - receive yellow card for a foul. |
| 73' | | Missed chance. Tanguy Ndombélé - Napoli - shot with right foot from outside the box goes high. Assist - Giovanni Di Lorenzo. |
| 74' | | Fouled by Mário Rui - Napoli |
| 74' | | Mehdi Léris - Sampdoria - won a free kick on the right wing. |
| 77' | | Corner - Napoli. Conceded by Tommaso Augello. |
| 77' | | Missed chance. Piotr Zielinski - Napoli - shot with right foot from outside the box goes high. Assist - Tanguy Ndombélé after corner. |
| 78' | | Penalty conceded by Ronaldo Vieira - Sampdoria - with a hand ball in the penalty area. |
| 80' | | Delay in match - Napoli VAR checking. |
| 80' | | VAR Decision: Penalty Napoli. |
| 80' | | Delay over. They are ready to continue. |
| 81' | | Goal! Sampdoria 0, Napoli 2. Eljif Elmas - Napoli - converts the penalty with a shot with right foot to the high centre of the goal. |
| 83' | | Substitution - Sampdoria. Daniele Montevago for Sam Lammers. |
| 83' | | Substitution - Sampdoria. Flavio Paoletti for Ronaldo Vieira. |
| 87' | | Substitution - Napoli. Giacomo Raspadori for Eljif Elmas. |
| 90' | | Hand ball by Giacomo Raspadori - Napoli |
| 90+1' | | Daniele Montevago - Sampdoria - won a free kick on the left wing. |
| 90+1' | | Fouled by Amir Rrahmani - Napoli |
| 90+2' | | Missed chance. Victor Osimhen - Napoli - shot with right foot from the centre of the box is high and wide to the right. Assist - Giacomo Raspadori. |
| 90+3' | | Fouled by Daniele Montevago - Sampdoria |
| 90+3' | | Mário Rui - Napoli - won a free kick in defence. |
| 90+3' | | Fouled by Bram Nuytinck - Sampdoria |
| 90+3' | | Victor Osimhen - Napoli - won a free kick on the left wing. |
| 90+5' | | Shot blocked. Giacomo Raspadori - Napoli - shot with left foot from the right side of the box is blocked. |
| 90+5' | | Corner - Napoli. Conceded by Nicola Murru. |
| 90+5' | | Second Half ended - Sampdoria 0, Napoli 2. |
| | Thats all. Game finished - Sampdoria 0, Napoli 2. |