Inter kept a grip on top spot by drawing with Juventus in last week's Derby d'Italia, before fighting back to hold Benfica in the Champions League; their hosts won the first match of Walter Mazzarri's second spell in charge, but then lost to Real Madrid.
Last week, a 2-1 victory away to Atalanta BC kicked off the new Walter Mazzarri era in style, as Napoli kept themselves within range of Serie A's serious Scudetto contenders thanks to a late winner from Eljif Elmas.
Briefly - and unsuccessfully - Inter manager after leaving Naples back in 2013, Mazzarri recently returned to Campania as Rudi Garcia's replacement, and following his initial impact, the Partenopei reduced their deficit to the table-topping Nerazzurri down to eight points.
Hoping to ride the crest of a wave, the Italian champions returned to continental competition in midweek, as Group C's top two met in a Champions League cracker.
Another familiar face, ex-Napoli boss Carlo Ancelotti, led his current club to a 4-2 win at the Bernabeu on Wednesday evening, as Real Madrid cemented first place with a couple of late goals, after Giovanni Simeone and Frank Anguissa had both scored for the visitors.
Although second spot is not yet wrapped up, Mazzarri's men remain hot favourites to join Real in the last 16, and at the very least Napoli have secured their fifth successive progression through a UEFA competition group phase.
Of course, last year's quarter-finalists would prefer to continue in Europe's top tournament rather than slip into the Europa League, but before meeting Braga for their Group C finale, they must first tackle Inter and then old foes Juventus.
As Napoli have lost just one of 17 Serie A home matches against Inter this century, history is certainly on their side this weekend, when victory would see them further close the gap to their visitors in the standings.
Having found the net in each of their last 10 league fixtures against Napoli, Inter have also won five of the teams' last eight top-flight meetings; however, most of those successes came on Milanese soil.
The Nerazzurri were beaten 3-1 on their last visit to Stadio Maradona back in May, when Napoli were beginning their elongated victory parade as Scudetto winners, but both sides' fortunes have changed since that day.
While Sunday's hosts have faltered in their defence of the title, Inter's grim draw away to bitter rivals Juventus last week saw their unbeaten run - a streak featuring eight wins - reach its 10th game, although Juve seized the summit with Friday's late win over Monza.
Following a six-goal thriller against Benfica, in which Simone Inzaghi's side battled back impressively from three goals down at half time, Inter's only loss after 17 matches in all competitions remains a shock defeat to Sassuolo in late September.
Last term's beaten finalists had already confirmed their presence in the Champions League's last 16, but after a tough test in Lisbon, Inzaghi's men now complete a tricky trilogy by travelling down south to Naples.
While Inter have won nine of their last 11 Serie A away matches, scoring at a rate of 2.4 goals per game, their modest record at Stadio Maradona suggests such supremacy may be more difficult to maintain this weekend.
After Piotr Zielinski limped off in Madrid on Wednesday night, Napoli may be forced to make a change in midfield, so last week's matchwinner Eljif Elmas is on standby to start instead.
Mathias Olivera (knee) has joined fellow left-back Mario Rui (adductor) on the sidelines due to injury, and with no other specialist in the squad, Walter Mazzarri could call upon ex-Inter centre-back Juan Jesus to fill in.
Sure to start up front following his return to full fitness - replacing Giovanni Simeone - Victor Osimhen (32) joins Inter captain Lautaro Martinez (34) in having racked up more Serie A strikes than anyone else since the start of last season. Across Europe's top five leagues, only Erling Haaland, Harry Kane and Kylian Mbappe stand ahead of them.
Current leader of the Capocannoniere rankings, which Osimhen topped last term, Martinez has 27 league goals to his name in 2023: only two Inter players have scored more in a calendar year during the 21st century: Diego Milito (28 in 2012) and Christian Vieri (28 in 2001).
Napoli possible starting lineup:
Meret; Di Lorenzo, Rrahmani, Natan, Jesus; Anguissa, Lobotka, Elmas; Politano, Osimhen, Kvaratskhelia
Inter Milan possible starting lineup:
Sommer; Darmian, De Vrij, Acerbi; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Thuram, Martinez
We say: Napoli 2-2 Inter Milan
Napoli and Inter have taken more shots, had more touches in the opposition area, and scored more goals (26 vs 30) than any other clubs in Serie A this season. Surely, then, a lifeless stalemate will not play out in front of the Neapolitan faithful: expect entertainment.
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