While Blues have dropped out of the top six in the table, QPR are currently keeping themselves out of the relegation zone, helped by securing a late point versus Swansea City earlier this week.
Before the international break, Birmingham were going quietly about their business, with head coach John Eustace putting together a five-match unbeaten streak with three wins and two draws.
However, like it did with Michael Beale - who was coincidentally with QPR - links to Rangers have preceded a run of defeats, with Blues losing at Watford and Preston North End respectively.
Those defeats should be put into context with Watford scoring two late goals to beat their 10-men opponents and leaders Preston coming from behind to edge out Eustace's side by a 2-1 scoreline.
Nevertheless, despite Eustace's obvious qualities and Birmingham being in a position where they can still be pleased with their start to the season, they need another victory as soon as possible.
On the back of a four-match winning streak in all competitions, Birmingham have now failed to prevail in the same amount of matches since August 29.
From QPR's perspective, they are still yet to find any consistency under Gareth Ainsworth, keeping their boss under pressure on a game-by-game basis.
For now, though, Ainsworth is doing an acceptable job, collecting seven points from as many matches with four points coming from a possible nine either side of the international break.
QPR had appeared on course for a fifth defeat in seven when trailing Swansea for much of their fixture at Loftus Road on Tuesday, before Lyndon Dykes powered a header into the corner in the first-minute of added-on time.
These two clubs have spent the early weeks of the season at opposite ends of the standings, yet an away success at St Andrew's on Friday would take QPR to within one point of their hosts.
Birmingham will be able to welcome back Lee Buchanan after the defender served his one-match suspension for his dismissal at Watford.
Having not been rushed back from an injury suffered in August, four substitute outings for country and club may lead to Dykes being recalled in place of Sinclair Armstrong.
While other alterations could be considered, Ainsworth may be content to go with the side that started against Swansea, particularly with midfielder Jack Colback serving the second of a three-match ban.
Birmingham City possible starting lineup:
Ruddy; Drameh, Sanderson, Long, Longelo; Sunjic, Bielik; Anderson, Stansfield, Miyoshi; Hogan
Queens Park Rangers possible starting lineup:
Begovic; Kakay, Cook, Fox; Smyth, Dozzell, Field, Paal; Willock, Dykes, Chair
We say: Birmingham City 2-1 Queens Park Rangers
Unlike throughout the early weeks of the season, there is more momentum with the visitors heading into this contest. Nevertheless, Blues are under pressure to deliver maximum points to get back on track, and we feel that they will net during the latter stages to edge a tight encounter.
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