Strasbourg vs. Bordeaux (Wednesday, 6.00pm)
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On the back of three consecutive draws, Strasbourg will look to stretch their league unbeaten run to five games on Wednesday, when they play host to Bordeaux.
A steady improvement in form has seen the hosts climb to eighth spot in the Ligue 1 table, while their visitors sit 16th, having failed to win any of their last three games.
We say: Strasbourg 2-0 Bordeaux
Taking on a vulnerable Bordeaux side, we see Strasbourg extending their impressive run of form on Wednesday.
The visitors are known to be leaky at the back, and they could be outclassed away from home against a side who have started to grind out results consistently.
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Troyes vs. Lorient (Wednesday, 6.00pm)
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Lorient will look to put an end to a run of eight games without a win in Ligue 1 on Wednesday, when they travel to take on Troyes.
Despite their struggles, the visitors sit two points better off than their opponents, who find themselves level with Clermont in the bottom three.
We say: Troyes 1-1 Lorient
With the two teams devoid of confidence and struggling for form, we predict a cagey encounter on Wednesday and expect it to finish level.
While the visitors' form is noticeably poor, they meet a Troyes side in a slump of their own, and Pelissier's side should, at least, be able to arrest their losing run.
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Metz vs. Montpellier (Wednesday, 6.00pm)
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After winning for only the second time this season, Metz can do something that they have yet to do in the 2021-22 Ligue 1 campaign, win at home, and they have a chance to do that on Wednesday, playing host to Montpellier HSC at Stade Saint-Symphorien.
Les Grenats are in 19th place following their 1-0 win versus Nice over the weekend, while La Paillade have dropped consecutive league fixtures after winning two in a row, losing 1-0 to Lyon on Sunday.
We say: Metz 0-2 Montpellier HSC
Metz may be coming off a high note which is not the case for Montpellier, but they have been poor at home for a long time and have not beaten La Paillade in Metz in their previous three fixtures against them.
Losing consecutive matches is rare for Montpellier, and we do not expect that trend to continue, given the experience of this squad compared to their opponents on Wednesday.
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Brest vs. St Etienne (Wednesday, 6.00pm)
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Saint-Etienne return to action in Ligue 1 on Wednesday with an opportunity to climb out of last place when they head to Stade Francis-Le Ble for a date with Brest.
Les Verts had their four-game unbeaten run snapped by PSG over the weekend, losing 3-1, while Les Pirates have won four in a row after coming back to beat Bordeaux 2-1 on Sunday.
We say: Brest 2-1 Saint-Etienne
Brest are playing inspired football at the moment with six goals, and none against in their previous two road matches, and they should not have any trouble scoring against a side like Les Verts, who have allowed the most goals in the league (31) and have conceded 17 times in seven matches away from home.
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Angers vs. Monaco (Wednesday, 6.00pm)
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Two surprise stories for different reasons will face each other on Wednesday to kick off the final month of 2021 in Ligue 1 as Angers host Monaco at Stade Jean-Bouin.
The small club based in Western France are off to an excellent start, currently in sixth in the table and unbeaten in their last three games, while Les Monegasques have struggled domestically, going winless in four straight contests, presently sitting in ninth.
We say: Angers 0-1 Monaco
Angers have lost three straight games against Monaco and have not beaten them since January 2016, and as good as they have been so far in this campaign, there are still moments where they allow too much space in their third of the field like they did against Lens over the weekend.
Monaco should have plenty of possession in this one, and they can afford to put a stronger side together for these league contests for a little while, with a spot in the next phase of the Europa League already guaranteed.
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Nantes vs. Marseille (Wednesday, 8.00pm)
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Fourth-placed Marseille travel north-west to the Stade de la Beaujoire to take on Nantes in Wednesday evening's Ligue 1 action.
The two sides are heading in opposite directions - the hosts are winless in four matches whilst their upcoming opponents are unbeaten in six.
We say: Nantes 1-2 Marseille
Marseille have probably overcome enough adversity during this season to convince them that nothing can stand in their way. Games involving Nantes tend to see both teams score so we are backing a 2-1 away win on this occasion.
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PSG vs. Nice (Wednesday, 8.00pm)
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Runaway leaders Paris Saint-Germain welcome Nice to the Parc des Princes on Wednesday evening for midweek action in the 16th round of Ligue 1 fixtures.
The hosts bounced back from a disheartening loss in Europe with a win at the weekend, whilst their upcoming opponents slipped to a second consecutive home defeat.
We say: Paris Saint-Germain 2-1 Nice
The hosts will miss Neymar but are potentially fortunate in their timing of meeting Nice, who have hit their first rough patch of form since Galtier took over. As we have learnt, it may be best for PSG to concede first but, either way, we back them to be ahead by the final whistle.
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> How PSG could line up against Nice
Rennes vs. Lille (Wednesday, 8.00pm)
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High-flying Rennes welcome reigning champions Lille to Roazhon Park on Wednesday evening with the former playing far more like title-holders than their upcoming opponents.
The hosts moved up to second in the table with another win at the weekend, whilst a draw saw the visitors fall further into the bottom half.
We say: Rennes 1-1 Lille
The form book points to an easy Rennes win, but Lille have been getting closer to finally earning another three points and will be determined to make amends for what could have been at the weekend. All things considered, we expect the two sides to somewhat cancel each other out and share the spoils.
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Clermont vs. Lens (Wednesday, 8.00pm)
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Clermont play host to Lens on Wednesday, in an important game at both ends of the Ligue 1 table.
The visitors have dropped to fifth after a small slump in form, while their hosts currently occupy the relegation playoff place with just a one-point lead over the bottom two.
We say: Clermont 0-2 Lens
While Lens are far from their best, they meet a Clermont side lacking any confidence and should be able to get over the line.
Since the rapid start, the hosts have struggled to adjust to life in the top flight, and we see them being brushed aside by a strong Lens team.
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Lyon vs. Reims (Wednesday, 8.00pm)
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Lyon welcome Reims to the Groupama Stadium on Wednesday evening for the 16th round of Ligue 1 matches.
The hosts are in good form and sit 7th in the table despite having a game in hand, whilst the visitors are down in 14th but come into the game on the back of their first win in a while.
We say: Lyon 2-1 Reims
Even without their home support, Lyon should have enough to see off a Reims team who do not fare well on the road. We are backing a narrow victory for Les Gones on this occasion.
