Brentford vs. Southampton (Saturday, 3.00pm)
Both clubs look safe from relegation in 14th and 15th respectively and on 40 points apiece with three games left to play, while victory for either this weekend could lift them up into the top half of the table.
We say: Brentford 2-1 Southampton
End-of-season encounters when neither club has a great deal to fight for can be particularly unpredictable, but the form book points towards a Brentford win in this one - so long as they can prove that Monday's defeat to Manchester United was merely a blip.
Southampton have been shipping a lot of goals lately, and with the likes of Eriksen and Toney in Brentford's ranks, we believe that could be enough for the hosts to come away with all three points this weekend.
Burnley vs. Aston Villa (Saturday, 3.00pm)
The Clarets have enjoyed a dramatic turnaround in fortunes in recent weeks to climb out of the bottom three, but they remain only two points clear of danger with four games remaining.
We say: Burnley 1-0 Aston Villa
All eyes should be on the opening 15 minutes in this match; Villa have conceded a league-high 22% of their goals in that period, while only Man City have scored a higher share of their goals in that spell than Burnley.
If Villa do survive that period then their chances of success should greatly improve - you have to go back to December 5 for the last time they won a game in which they conceded - but Burnley will be fighting for their lives and it is difficult to look past their recent form.
The new manager bounce may not last until the end of the season, but a home tie against a Villa side that is now effectively safe from relegation is about as kind a fixture as Burnley could hope for at this stage of the season.
Chelsea vs. Wolves (Saturday, 3.00pm)
The Blues went down 1-0 to a relegation-threatened Everton last weekend, while Bruno Lage's side were humbled by Brighton & Hove Albion in front of their own fans in a 3-0 loss.
We say: Chelsea 2-1 Wolverhampton Wanderers
Chelsea's multiple errors at Stamford Bridge and options for change in attack makes this an interesting proposition for Wolves, who will be more desperate than ever to give their fans something to cheer and keep their fleeting European hopes alive.
The latest developments surrounding the future of the club could lead to an abject mood around the capital stadium here, but Wolves' attacking failures away from home leads us to back the Blues to return to winning ways.
Crystal Palace vs. Watford (Saturday, 3.00pm)
At best, the departing Roy Hodgson's return to his former club could grant Watford a stay of execution should other results also go their way, but relegation to the Championship is now a matter of when, rather than if.
We say: Crystal Palace 2-0 Watford
Relegation can sometimes allow clubs to play with the shackles off, so some improvement may come from Watford in the closing weeks of the season, but right now they are still in the limbo of knowing that they are effectively down, without the mathematical confirmation.
That is likely to come this weekend, and with Hodgson also departing, there is a danger that the Hornets could give up on this season and begin to focus on life back in the Championship.
Palace, meanwhile, still have goals for the campaign and so we are predicting them to pick up a relatively comfortable win this weekend.
Our analysis of all available data, including recent performances and player stats, suggests the most likely outcome of this match is a Crystal Palace win with a probability of 60.94%. A draw has a probability of 22.4% and a win for Watford has a probability of 16.63%.
The most likely scoreline is Crystal Palace 1-0 Watford with a probability of 12.77% and the second most likely scoreline is Crystal Palace 2-0 Watford with a probability of 11.67%.
Brighton vs. Man Utd (Saturday, 5.30pm)
Both seeking to build on 3-0 wins in their most recent Premier League encounters, Brighton & Hove Albion and Manchester United prepare for battle at the Amex on Saturday evening.
Graham Potter's side humbled Wolverhampton Wanderers at Molineux last weekend, while the Red Devils enjoyed a confidence-boosting success over Brentford.
We say: Brighton & Hove Albion 1-1 Manchester United
One of the Premier League's worst performing teams at home facing a Man United side who cannot stop losing on the road is a fascinating matchup for sure, and the Seagulls know a thing or two about taking points off of Champions League-chasing sides.
Timeless veteran Ronaldo is always capable of producing the goods when it matters most for this Man United side, but we would not be surprised to see the giant-killing Seagulls hang on for a point here.
Liverpool vs. Spurs (Saturday, 7.45pm)
Fresh from booking their place in a third Champions League final from the last five seasons, Jurgen Klopp's side play their penultimate home game of an unforgettable campaign against a team with plenty riding on the fixture themselves.
We say: Liverpool 3-2 Tottenham Hotspur
This is not a match many Liverpool fans will be looking forward to; Spurs have the tools to expose Liverpool's few weaknesses, and if the Reds do get their high line wrong against Kane and Son then they will be punished more severely than against most teams.
Most of Liverpool's dropped points this season have come in the more frantic games - something Spurs will look to make it having beaten Man City in similar fashion, particularly as they realistically need the win themselves.
However, it is impossible to look past Liverpool's recent record of 40 points from the last 42 available in the Premier League, and they proved again in midweek that they have a welcome habit of finding a way to get the job done.
This fixture is the second-highest scoring one in Premier League history and we expect goals again, but ultimately it is difficult not to come down on the side of Liverpool picking up a priceless win which would again lift them to the top of the table.
Our analysis of all available data, including recent performances and player stats, suggests the most likely outcome of this match is a Liverpool win with a probability of 73.88%. A draw has a probability of 16.3% and a win for Tottenham Hotspur has a probability of 9.82%.
The most likely scoreline is Liverpool 2-0 Tottenham Hotspur with a probability of 12.35% and the second most likely scoreline is Liverpool 1-0 Tottenham Hotspur with a probability of 10.31%.