Anfield will host the latest instalment of the Merseyside derby, as Premier League champions and current division leaders Liverpool welcome Everton in Saturday's early start.
Saturday's late kickoff sees Manchester United host Chelsea, with the 20-time English champions in desperate need of a victory following their defeat to Manchester City in the Manchester derby.
However, arguably the standout match in gameweek five comes at the Emirates Stadium on Sunday afternoon, as title rivals Arsenal and Man City prepare to lock horns in what is shaping up to be a fascinating affair.
In the fifth set of fixtures, Sports Mole are facing off against Man United fan Warren "Dermo" Dermody from Manchester group Northside.
Read on to discover Dermo's and our predictions for gameweek five of the 2025-26 campaign, in addition to a look at how rapper Piers James performed in the fourth set of fixtures this season.
Liverpool vs. Everton
Saturday, 12.30pm
Dermo: Liverpool 1-1 Everton
Sports Mole: Liverpool 2-0 Everton
Taking into account how both teams have started the new season and their records against one another in the Merseyside derby, it is difficult not to back Liverpool securing all three points at Anfield this weekend.
A resurgent Everton side, who have looked strong defensively this term, have the potential to frustrate Liverpool in a similar fashion to Burnley last time out, but we expect the Slot machine to churn out another victory to preserve their perfect start to 2025-26.
Burnley vs. Nottingham Forest
Saturday, 3pm
Dermo: Burnley 1-2 Nottingham Forest
Sports Mole: Burnley 1-1 Nottingham Forest
Burnley may have lost three of their four league matches, but the Clarets have been competitive in every game this term, and we expect another strong performance when they host Nottingham Forest.
The Tricky Trees have had a disastrous start under Postecoglou, and while we expect an improved performance against Burnley on Saturday, we believe the new manager will be kept waiting for his first win, as we predict this game to end all square.
Brighton & Hove Albion vs. Tottenham Hotspur
Saturday, 3pm
Dermo: Brighton 2-1 Tottenham
Sports Mole: Brighton 1-2 Tottenham
If history is anything to go by, a draw may not be on the cards this weekend as each of the last 15 meetings between Brighton (six) and Spurs (nine) across all competitions have produced a winner.
Spurs have not enjoyed their recent trips to the Amex, but they look a much stronger outfit under Frank this term and we are backing the North Londoners to outscore a Seagulls side who have not looked wholly convincing in the early stages of the new campaign.
West Ham United vs. Crystal Palace
Saturday, 3pm
Dermo: West Ham 1-1 Crystal Palace
Sports Mole: West Ham 1-1 Crystal Palace
Despite the heaviness of the Spurs defeat last time, West Ham were able to take some positive from individual performances and should be targeting Saturday's match in an attempt to end their losing run at home.
Crystal Palace could be without Wharton, Sarr and Nketiah for this match, limiting their options in midfield and attacking areas - a scarcity which could lead to a frustrating draw in East London.
Wolverhampton Wanderers vs. Leeds United
Saturday, 3pm
Dermo: Wolves 1-2 Leeds
Sports Mole: Wolves 1-2 Leeds
In a real rut at the start of the season and potentially without Strand Larsen once again, Wolves could struggle during the visit of Leeds this Saturday.
After a heartbreaking end to their Fulham trip, Farke's side will be chomping at the bit to collect maximum points in the Black Country on the weekend.
Saturday, 5.30pm
Dermo: Man United 2-2 Chelsea
Sports Mole: Man United 0-2 Chelsea
There has been little to separate these two teams over the years. In fact, Chelsea versus Man United is the most drawn fixture in Premier League history, finishing level 27 times, with 14 of those draws having been played out at Old Trafford.
Another closely-contested encounter could be on the cards this weekend, but Chelsea should feel that Man United are there for the taking in their current state. Amorim is in desperate need of a positive result, but we can see the Blues bouncing back from their midweek loss to claim maximum points in Manchester.
Fulham vs. Brentford
Saturday, 8pm
Dermo: Fulham 1-0 Brentford
Sports Mole: Fulham 1-1 Brentford
There has been little to separate these two West London teams in recent years, as both Fulham and Brentford have won four games each across the last nine meetings in all competitions (D1).
Another tight, yet entertaining, contest is in store this weekend, and although the Bees did the double over the Cottagers last season, we are backing the hosts to claim at least a share of the spoils on this occasion.
Sunday, 2pm
Dermo: Sunderland 1-1 Aston Villa
Sports Mole: Sunderland 2-2 Aston Villa
Aston Villa's midfield may be more vulnerable without the presence of both Onana and Tielemans, and their backline could subsequently be exposed.
Sunderland will still almost certainly concede chances if the visitors make changes in attack, but the Stadium of Light could help them gain at least a point on Sunday.
Bournemouth vs. Newcastle United
Sunday, 2pm
Dermo: Bournemouth 2-1 Newcastle
Sports Mole: Bournemouth 2-1 Newcastle
While Bournemouth have made a strong start to the season, Newcastle have struggled to find their footing thus far, and with a difficult trip to the Vitality next up for the Magpies, we expect another disappointing result for Howe's side, with the Cherries are pick to win this one.
Arsenal vs. Manchester City
Sunday, 4.30pm
Dermo: Arsenal 2-2 Man City
Sports Mole: Arsenal 2-1 Man City
Showing little signs of weakness at the Emirates or anywhere for that matter this term, Arsenal should be confident of picking up a statement victory, even without the likes of Saka and Odegaard causing havoc.
In a reversal of roles compared to recent years, you feel that it is Manchester City’s title credentials on test in North London, where the Gunners should continue their excellent run against the Citizens.
Warren "Dermo" Dermody Q&A
How did you come to support Man United and what are your favourite memories from your time as a fan?
Dermo: My Dad got me into United when I was a kid, about seven. I remember him taking me to Old Trafford and I loved it - the atmosphere, the singing and the football. The treble in 1999 is my standout memory. Watching it in the boozer with all my pals and the place erupting when Ole stuck the winner in.
Who have been your favourite five players for Man United?
Dermo: [Eric] Cantona, [Roy] Keane, [Paul] Scholes, [Denis] Irwin, [Ruud] van Nistelrooy
What's going on with the band at the moment?
Dermo: Northside are currently writing and recording a new album, due for release in the summer of 2026. Going on tour with Happy Mondays and The Farm early 2026. Lot's more going on but can't announce yet!
You can follow Northside on Instagram and X.
2025-26 SEASON LEADERBOARD (ARTISTS)
Scores are calculated as one point for a correct result and five points for a correct scoreline.
1. Piers James (9pts | Gameweek 4)
2. Georgia (8pts | Gameweek 1)
3. Picture Parlour's Katherine Parlour (4pts | Gameweek 3)
4. Patrick King from Real Lies (2pts | Gameweek 2)
2025-26 COMPETITION HISTORY
Gameweek 1: Georgia 8-10 Sports Mole
Gameweek 2: Real Lies' Patrick King 2-8 Sports Mole
Gameweek 3: Picture Parlour's Katherine Parlour 4-5 Sports Mole
Gameweek 4: Piers James 9-6 Sports Mole