The 30-year-old became the first openly gay male professional athlete in US pro sports four years ago when initially announcing his retirement.
Rogers, also the first openly gay professional footballer since Justin Fashanu in 1990, overturned his previous decision three months later when offered the chance to play for LA Galaxy.
Seventy-eight Major League Soccer appearances would follow, before bowing out for good after missing the duration of the 2017 season with a foot injury picked up in May.
"It is with mixed emotions that I announce my retirement from the game of soccer," he said in a statement. "It is through this game that I have experienced some of my greatest achievements both professionally and personally.
"I leave the game full of pride of what I have accomplished as a person and a player. I am looking forward to the next chapter of my life."