The home side have fallen off the pace in the race for a European finish after winning just two of their 10 league games since the turn of the year.
Twente were involved in a 2-2 draw for the second game running as they were held by Heracles Almelo on Saturday at the Erve Asito.
The Tukkers have moved above Utrecht into seventh place on the log, following the latter's loss to Emmen in the last round of matches.
However, they remain eight points behind Feyenoord in the battle for fifth spot, and with just 10 games left to play, they face an uphill task of securing a spot in next season's Europa League.
Saturday's hosts head into the clash with a chance to complete a league double over their visitors, who were beaten 3-0 in October's reverse fixture.
Coming off the back of heavy defeats to Utrecht and Feyenoord, Willem II have bounced back in style, picking up four points from the subsequent two games.
Mike Tresor was the star of the show, supplying a goal and an assist en route to a relatively comfortable victory for his side.
The Tricolores have now moved within five points of safety, and things are looking up for them as the season enters into its last knockings.
FC Twente Eredivisie form: DDLWDD
Willem II Eredivisie form: LWLLDW
Following his leveller last time out, Danilo is now up to 13 Eredivisie goals in his first season as a regular starter, and he will back himself to still add to that already impressive tally.
Willem's Dries Saddiki will not play a part in this one as he steps up his recovery from a muscle tear which he sustained over five weeks ago.
Joining him on the list of absentees for the visitors is Miquel Nelom, whose season has been prematurely ended with a knee injury.
Freek Heerkens will also miss the game as he remains out with a thigh injury through which he has missed his side's last seven games.
FC Twente possible starting lineup:
Drommel; Dumic, Pierie, Pleguezuelo, Smal; Zerrouki, Roemeratoe, Bosch; Menig, Danilo, Van Leeuwen
Willem II possible starting lineup:
Brondeel; Kohn, Peters, Holmen, Owusu; Kohlert, Selahi, Spieringhs, Nunnely; Pavlidis, Okyere Wriedt
We say: FC Twente 2-1 Willem II
The visitors have undeniably improved their performances in recent weeks as they seek to stay afloat. That being said, we are backing the home team to carry the day, and put a dent in the away side's survival hopes.