Real Madrid head coach Xabi Alonso could make multiple changes to his starting side for Wednesday's Champions League contest with Olympiacos in Greece.
Los Blancos switched to a back three for the La Liga contest with Elche on Sunday, but they could only draw 2-2, and the team's winless run in all competitions has now stretched to three matches.
Antonio Rudiger (muscle), David Alaba (muscle), Dani Carvajal (knee), Eder Militao (groin) and Franco Mastantuono (groin) have been joined on the sidelines by Thibaut Courtois (illness) and Dean Huijsen (discomfort).
However, Aurelien Tchouameni (hamstring) is back in the squad, and the France international is likely to feature in the middle of the defence.
Vinicius Junior, Federico Valverde and Eduardo Camavinga were used off the bench against Elche, and the trio are now expected to be introduced into the starting team on Wednesday night.
There should be a switch back to a defensive four, with Trent Alexander-Arnold likely to keep his spot at right-back, while Raul Asencio is again in line to feature in the middle of the defence.
Fran Garcia, Dani Ceballos and Rodrygo could be the three players to drop out, with Jude Bellingham potentially playing just behind a front two of Vinicius and Kylian Mbappe.
Real Madrid possible starting lineup: Lunin; Alexander-Arnold, Asencio, Tchouameni, Carreras; Valverde, Camavinga, Guler; Bellingham; Mbappe, Vinicius