Birmingham vs. Derby (Wednesday, 7.30pm)
The Blues have failed to win any of their last 13 matches and are two points above the dropzone ahead of this final-day clash with Derby, who can finish no higher than 10th.
We say: Birmingham City 1-1 Derby County
Birmingham supporters will be wondering just how their survival fight has gone down to the last game. Derby have also been in poor form, albeit without the threat of relegation, and we are expecting this one to finish all square.
Brentford vs. Barnsley (Wednesday, 7.30pm)
The hosts are in contention for automatic promotion, albeit with their top-two hopes no longer in their own hands, while Barnsley are still alive in the race to beat the drop.
We say: Brentford 2-0 Barnsley
Missing out on automatic promotion would be massively cruel on Brentford, but all they can do is get the job done against Barnsley and hope for the best. The visitors picked up a huge win at the weekend and will be in high spirits here, but the Bees are unbeaten at Griffin Park since January and we cannot see that changing.
Bristol City vs. Preston (Wednesday, 7.30pm)
Both teams were in strong contention for a playoff spot before the three-month interruption, but neither can make the top six heading into this final game of the season.
We say: Bristol City 0-1 Preston North End
Both teams have struggled in the second half of the campaign and will wonder what might have been with a little bit more consistency. Preston did at least pick up a morale-boosting victory last time out and boast an imperious record, so we are tipping them to pick all three points.
Cardiff vs. Hull City (Wednesday, 7.30pm)
The Bluebirds need a point to guarantee a top-six finish, while Hull are also in need of all three points - plus a helping hand from elsewhere - to have any hope of avoiding relegation.
We say: Cardiff City 2-0 Hull City
The pressure is still on Cardiff heading into this final regular season fixture, knowing that a shock defeat will open the door for Swansea to pounce. The Bluebirds have been in good form since last month's restart, though, while Hull have won just twice in 2020, so we can only see this game finishing one way.
Leeds vs. Charlton (Wednesday, 7.30pm)
Marcelo Bielsa's side have already secured promotion to the Premier League after a 16-year absence heading into the contest at Elland Road, but it is still all to play for as far as relegation-threatened Charlton are concerned.
We say: Leeds 2-2 Charlton
The league table and the form book both point firmly to a home win in this match, and at any other stage of the season this would be a relatively straightforward prediction, with no team having lost fewer home games than Leeds this term and no team having won fewer than Charlton.
However, the final day is notorious for throwing up unexpected results and, with Charlton knowing that victory keeps them in the division, they are in much greater need of the points than the hosts. Nevertheless, Leeds will want to finish their season in style, so we can see those two elements cancelling each other out in an entertaining draw.
Luton vs. Blackburn (Wednesday, 7.30pm)
While Rovers make the trip to Kenilworth Road with little to play for, Tony Mowbray's side can still finish as high as eighth position in the standings.
We say: Luton Town 1-2 Blackburn Rovers
While Luton have home advantage and something to play for, that may only increase the chances of Blackburn inflicting a defeat on their hosts. However, with much dependent on how Charlton are faring against Leeds, it is difficult to predict the final outcome with any great deal of confidence.
Millwall vs. Huddersfield (Wednesday, 7.30pm)
The home side can still finish as high as seventh in the table if they prevail at the Den on Wednesday evening, while the visitors, although not mathematically safe, know that another three points will ensure that they end the campaign no lower than 18th position.
We say: Millwall 3-1 Huddersfield Town
With Huddersfield lacking a permanent manager and players likely to be contemplating their futures, everything points to Millwall taking advantage in an open game of football in East London.
Nott'm Forest vs. Stoke (Wednesday, 7.30pm)
Meanwhile, the Potters make the short trip to the City Ground having secured their place in the second tier for another 10 months with victory over promotion-chasing Brentford at the weekend.
We say: Nottingham Forest 1-1 Stoke City
With survival having already been secured, Stoke may relish the chance to play with freedom on Wednesday night. However, Forest will be motivated to ensure that they do not waste a prolonged period in the top six, leading us to predict a competitive draw.
Reading vs. Swansea (Wednesday, 7.30pm)
The Royals welcome the Swans to the Madejski Stadium sitting in 15th position after suffering defeats in their last two matches.
We say: Reading 1-3 Swansea City
With the mentality that only three points will do, we expect Swansea to battle their way to victory over Reading, who may struggle to cope in defence if the visitors find their stride.
Sheff Weds vs. Middlesbrough (Wednesday, 7.30pm)
Middlesbrough are still at risk of relegation with just one game left to go, but it seems highly unlikely that Boro will go down at this very late stage.
We say: Sheffield Wednesday 1-2 Middlesbrough
Warnock has done well to lift Boro further up the table and the Teesiders should not suffer relegation now. Wednesday do not inspire much confidence at home, so we are backing Boro to secure their safety with a slender victory on the final day.
West Brom vs. QPR (Wednesday, 7.30pm)
West Brom currently sit one point above third-placed Brentford after 45 matches, while QPR sit 14th and realistically have little to play for on the final day.
We say: West Bromwich Albion 2-0 Queens Park Rangers
West Brom know what is at stake here - anything other than a win and their hopes of automatic promotion could be scuppered. However, they are facing a QPR side with a poor record away from home, so we are backing the Baggies to secure a route back to the Premier League with a routine victory on the final day.
Wigan vs. Fulham (Wednesday, 7.30pm)
Meanwhile, Wigan looked to have secured their safety in the second tier of English football, but the threat of relegation is looming following internal issues at the club.
We say: Wigan 3-2 Fulham
This is a difficult game to call. Both teams are in good spells of form and are in desperate need of a final three points for completely different reasons.
A win for either side may not make a difference to their promotion or relegation prospects depending on happenings on and off the pitch, but we are backing Wigan to scrape a narrow victory and leave their Championship status out of their own hands heading into the summer.