Both teams were in strong contention for a playoff spot before the three-month interruption, but neither can make the top six heading into this final game of the season.
Preston have spent more matchdays in the top six than they have out of it this term and had hold of a playoff spot when the coronavirus pandemic wreaked havoc with the schedule.
Indeed, Bristol City were North End's closest challengers at that point, sitting just one point worse off after dropping off the pace somewhat.
That alarming slide continued post-lockdown and cost Lee Johnson - the division's longest-serving manager at that point - his job as the Robins lost patience.
A nine-game winless run, including four straight defeats, has since become two wins, a draw and a defeat in their four matches under caretaker manager Dean Holden.
City's momentum was killed off at the weekend, though, with Famara Diedhiou missing from the penalty spot in their 1-0 defeat to Swansea City.
The Robins can no longer finish in the playoffs and that is also the case for Preston, who had won one out of 10 matches prior to Saturday's win against Birmingham City.
Alex Neil will now have one eye on next season, when another playoff push is expected, and this fixture provides Preston with a chance to build some momentum to see out 2019-20.
The Lilywhites are unbeaten in 13 league meetings with Wednesday's opponents and have won on their last five visits to Ashton Gate, all by a one-goal margin.
Furthermore, Bristol City have failed to win their final game in each of the last four seasons since an 8-2 win against Walsall on the final day of the 2014-15 League One season.
Bristol City's Championship form: LLWWDL
Preston North End's Championship form: LDWDLW
Nathan Baker injured his groin in the 1-1 draw with Stoke City last week and failed to pass a fitness test ahead of the Swansea match, so he is likely to sit this one out.
After coming on as a sub at the Liberty Stadium, fit-again Kasey Palmer will be pushing for a start in midweek.
Bristol City possible starting lineup:
Bentley; Vyner, Williams, Kalas; Hunt, Smith, Paterson, Dasilva; Palmer; Afobe, Wells
Preston North End possible starting lineup:
Rudd; Fisher, Storey, Bauer, Hughes; Ledson, Johnson, Rafferty; Brown; Barkhuizen, Maguire
We say: Bristol City 0-1 Preston North End
Both teams have struggled in the second half of the campaign and will wonder what might have been with a little bit more consistency. Preston did at least pick up a morale-boosting victory last time out and boast an imperious record, so we are tipping them to pick all three points.