The hosts enter the Super Lig contest in 13th place, while Adana Demirspor currently occupy ninth position.
Galatasaray have endured a disappointing campaign, and although they will be keen to see the back of the 2021-22 season, Monday's hosts still have the chance to move into the top half of the table.
The home side have fallen well short of last term's second-placed finish after spending the majority of the campaign in the bottom half of the Super Lig table.
Despite collecting just one point from their last two matches, the hosts will be hoping to give the fans something to cheer about in their final home game of the season
Their most recent home outing resulted in a 3-2 defeat to Sivasspor, which ended Galatasaray's five-game unbeaten home league run.
Although they may have lost in their previous game at the Nef Stadium, Domenec Torrent's side have won four of their last five home games in the Super Lig and a win on Monday would represent their 10th home league victory of the season.
The visitors, on the other hand, have fallen away from European contention in recent weeks following a poor run of results.
After 32 games, Adana Demirspor found themselves just one point adrift of the top four, but they have since wilted, with their last four matches all ending in defeat.
However, a 76th-minute strike from Emre Akbaba condemned Adana Demirspor to another defeat, leaving them in ninth position in the Super Lig.
Despite a European place now out of the question, the visitors will not want to take a winless run into the summer break, and they only have two games remaining in the season to make sure that is not the case.
Injury issues are expected to keep Marcao and Omar Elabdellaoui sidelined for Galatasaray, although they received a boost when Sofiane Feghouli returned to the matchday squad last week as an unused substitute.
Feghouli could be joined on the bench by Emre Kilinc, who is available after serving a one-match suspension.
As for the visitors, they could be without Benjamin Stambouli, who has missed the last three matches due to a muscle injury.
Matias Vargas dropped down to the bench last weekend, but the 25-year-old may return to the starting lineup for Monday's contest.
Meanwhile, Mario Balotelli is expected to lead the line for the hosts after coming back into the side to start in the defeat to Alanyaspor.
Galatasaray possible starting lineup:
Muslera; Boey, Nelsson, Ozturk, Van Aanholt; Babel, Kutlu, Antalyali, Pulgar, Akturkoglu; Gomis
Adana Demirspor possible starting lineup:
Muric; Cokcalis, Akaydin, Sanuc, Rassoul; Kurt, Inler; Akgun, Belhanda, Vargas; Balotelli
We say: Galatasaray 2-1 Adana Demirspor
Although Galatasaray have experienced a poor season, we think that four wins from their last five games will give them the confidence to clinch all three points in their final home match of the campaign, especially as Adana Demirspor are bereft of confidence after enduring a run of four consecutive defeats.
For additional data used by our team to analyse our suggested result please click here.