Midtjylland vs. Braga (Thursday, 5.45pm)
The visitors currently sit top of Group F on nine points, whilst their hosts are four points behind in third but still have a good chance of qualifying for the knockout rounds.
We say: FC Midtjylland 1-2 Braga
Whilst Midtjylland produced that impressive 1-0 win in their previous European game, they have lost their last two matches in the Danish Superliga - hardly ideal preparations for this important encounter.
We expect Braga to build on the confidence they will have gained from their big victory at the weekend and overcome the hosts' home advantage to secure a narrow win.
Red Star vs. Ludogorets (Thursday, 5.45pm)
The hosts lost top spot after a surprise defeat in the previous game and must now ensure they beat the group underdogs.
We say: Red Star Belgrade 2-0 Ludogorets Razgrad
Despite a weakened defence after those two red cards last time out, Red Star should still have enough to comfortably dispatch the group minnows. We are backing a comfortable 2-0 home victory.
Galatasaray vs. Marseille (Thursday, 5.45pm)
Jorge Sampaoli's men sit third in the group amid their streak of stalemates, whereas the Turkish hosts top the group with eight points to their name.
We say: Galatasaray 1-0 Marseille
Marseille may struggle to get into the right headspace for this encounter following the weekend's unsavoury events, and with the absent Payet at the heart of their attacks week in week out, Sampaoli's men are fighting an uphill battle to claim a first continental win of the season.
Galatasaray have produced defensive masterclass after defensive masterclass in Europe this term, and we are backing the group leaders to march to another narrow win as Marseille's draw streak ends in dismal fashion.
Lokomotiv vs. Lazio (Thursday, 5.45pm)
Maurizio Sarri's men sit second in the section with five points to their name, while their winless Russian hosts sit rock bottom of the rankings.
We say: Lokomotiv Moscow 0-1 Lazio
With no fewer than three creative midfielders absent for Lokomotiv, their chances of adding to a paltry two strikes in the Europa League are certainly slim against Sarri's Lazio.
The visitors will also continue to struggle for attacking inspiration if Immobile is not deemed fit to feature from the start, but Lazio should still nick the odd goal to march to victory here.
B. Leverkusen vs. Celtic (Thursday, 5.45pm)
We say: Bayer Leverkusen 2-1 Celtic
Celtic were well beaten against Leverkusen in September, but with the hosts to be without a few key players on Thursday, a closer affair could be on the cards this time around.
Nevertheless, the Germans will be the favourites for this contest and still have enough quality in their squad to secure all three points at the BayArena.
Real Betis vs. Ferencvaros (Thursday, 5.45pm)
Real Betis could consolidate second place in Group G of the Europa League if they can beat Ferencvaros in their penultimate match on Thursday evening.
The hosts have lost only one of their last seven home games across all competitions, while the visitors have won each of their last three away matches by an aggregate score of 13-0.
We say: Real Betis 2-0 Ferencvaros
With more riding on this fixture for Real Betis than already-eliminated Ferencvaros, the hosts will be the favourites to come away with all three points on Thursday.
Pellegrini is expected to name a strong side, which should have too much quality for their Hungarian counterparts.
Dinamo Zagreb vs. Genk (Thursday, 5.45pm)
Group H of the Europa League will be back in action this week as Dinamo Zagreb aim to go one step closer to securing their qualification to the knockout phase of the competition.
However, the visitors Genk will have the opportunity to overtake them in the table if they are able to be victorious on Thursday night.
We say: Dinamo Zagreb 3-1 Genk
A victory for Dinamo Zagreb could prove to be enough to progress if the other result goes their way and that should be enough incentive to get them over the line in this fixture.
Genk have struggled defensively throughout the competition and that is likely going to be a sticking point once again in this particular fixture.
Rapid Vienna vs. West Ham (Thursday, 5.45pm)
For the hosts, they must earn three points to stand any chance of progressing into the next round, placing a lot of importance on their performance.
We say: Rapid Vienna 0-3 West Ham United
This game means more to the hosts than it does to the Hammers, but that does not mean that it will be an easy one for them to secure a point in.
West Ham have a much stronger squad and plenty of options available due to the depth in the squad, which is why they should be able to get another victory here.
Rangers vs. Sparta Prague (Thursday, 8.00pm)
The two sides – who are level on four points in Group A – head into this contest off the back of disappointing domestic defeats at the weekend, and another loss for either team in Glasgow could end their hopes of advancing to the knockout rounds.
We say: Rangers 2-1 Sparta Prague
Both teams can seal their place in the last 32 of the Europa League with a victory on Thursday; however, a draw would be more beneficial to the visitors who have the better head-to-head record as things stand.
With a new manager at the helm for a European night under the lights at Ibrox, the home supporters will act as a 12th man for Rangers, which could help to get them over the line and secure a narrow victory.
Brondby vs. Lyon (Thursday, 8.00pm)
The hosts, meanwhile, sit at the bottom of the group but a surprise victory at the Brondby Stadion would boost their chances of finishing in the top two ahead of Rangers and Sparta Prague.
We say: Brondby 0-2 Lyon
Even if Lyon do decide to rotate their side, they will still be the strong favourites to come away with all three points on Thursday night.
The hosts still have something to play for, so they will likely throw everything at their French opponents, though the visitors should have no problems in securing a routine win.
PSV vs. Sturm Graz (Thursday, 8.00pm)
While the home side are focused on trying to qualify for the Europa League knockout stages, Sturm Graz need all three points to stay in the hunt for a Europa Conference League spot.
We say: PSV Eindhoven 2-0 Sturm Graz
Having rediscovered some form in recent matches, we feel that this could be a comfortable 90 minutes for PSV. While Graz have the freedom to go all out for victory, an early goal for the home side may derail them in their tracks.
Monaco vs. Real Sociedad (Thursday, 8.00pm)
While Sociedad are yet to lose any of their four group fixtures, defeat on Thursday may leave them requiring all three points on matchday six.
We say: Monaco 1-1 Real Sociedad
With Graz still to come on Matchday six, Kovac may not risk a defeat in search of all three points. With Sociedad potentially adopting the same mindset, do not be surprised to see this contest end in a low-scoring draw.
Leicester vs. Legia (Thursday, 8.00pm)
Separated by just a point and a place in the Group C table, Leicester City welcome Polish champions Legia Warsaw to the King Power Stadium on Thursday, for a potentially decisive Europa League encounter.
While Legia would be confirmed in the top two if they win and group rivals Spartak Moscow do not, the Foxes must avoid defeat and hope Napoli falter if they are to avoid either an early exit or finishing third - which means demotion to the Conference League.
We say: Leicester City 2-0 Legia Warsaw
With their visitors in complete disarray, this is the time for the Foxes to strike in Group C, as they face a tough trip to Naples in their final game.
Even if Leicester make a handful of changes, their squad players are more than capable of picking off an ailing Legia side which will surely sit back and hope to survive for 90 minutes.
Olympiacos vs. Fenerbahce (Thursday, 8.00pm)
However, the visitors could leapfrog them in the table and force things to go down to the final game of the group if they can secure a win.
We say: Olympiacos 1-1 Fenerbahce
There is a lot on the line for both teams heading into this match and that pressure could lead to quite a cagey affair taking place.
A draw would see both teams continue to battle for progression into the next round in the final match of the group, which is something that might happen between two even squads.
Frankfurt vs. Antwerp (Thursday, 8.00pm)
The hosts have already secured progression into the next round while it is impossible for the visitors to qualify, making this a game of pride more than anything.
We say: Eintracht Frankfurt 2-0 Royal Antwerp
It is hard to look past the hosts in this particular fixture considering the fact they have already wrapped up their qualification into the next round.
With the chance to secure a top-place finish Eintracht Frankfurt will no doubt be throwing everything at this, which should be enough to take them through.