The Gunners are flying high after reaching the knockout stage of the Champions League and will be eyeing another victory in their clash against Remi Garde's men.
Villa have endured a miserable campaign in the Premier League as they have not recorded a victory since the opening day of the season.
The club are seven points adrift of safety at the bottom of the table and the gap could widen before they take to the pitch against the Gunners on Sunday.
However, Garde's side did show a spark in their 1-1 draw against Southampton last week, and came close to earning the three points before Oriol Romeu's goal denied them victory.
Only Newcastle United, Bournemouth and Sunderland have conceded more than the Midlands club's 28 goals in the Premier League this term.
Villa have also struggled immensely at the other end of the pitch, being the joint-lowest scorers in the division with Stoke City on 13 goals. Jordan Ayew is the club's leading marksman this season with three goals.
Garde will be determined to improve his side's form at home to keep them in with a chance of remaining in the division. Villa have taken just two points from their seven matches at Villa Park this season, and beating his former club could kickstart a revival under the Frenchman.
Recent form: LLDLLD
Recent form (all competitions): LLDLLD
The Gunners will be buoyant after securing their place in the last 16 of the Champions League with a resounding 3-0 win over Olympiacos in Greece.
Wenger's side needed to produce a flawless performance and delivered in style as Olivier Giroud netted a hat-trick to ensure that his team would advance to the knockout stage of the competition.
Arsenal will now turn their attentions back to the Premier League where they will be determined to end their 12-year drought for the top-flight crown.
The Gunners managed to overcome a stubborn Sunderland side to claim a 3-1 victory at the Emirates Stadium to move above Manchester City in second place in the table, two points behind leaders Leicester City.
The Frenchman will be eyeing finishing the calendar year in top spot as crucial games await his team over the festive period, and Giroud has found his form at the right time for Arsenal to boost the fourth-most potent attack in the Premier League.
Arsenal have scored 27 goals in their 15 matches this term, but have also been resolute at the back, shipping just 13 strikes and keeping six clean sheets. However, the club's last shutout came in October against Swansea City, a run which Wenger will be determined to end.
The Gunners have been the second-best team on the road this season, losing just twice on their travels against Chelsea and West Bromwich Albion. They will be looking to continue their good form to move temporarily top of the table by claiming three points at Villa Park.
Recent form: WWDLDW
Recent form (all competitions): DLWDWW
Garde could recall midfielder Jack Grealish to the starting lineup after the 20-year-old was left out of the team for two matches as punishment for his off-the-field behaviour.
Leandro Bacuna and Rudy Gestede are both fit despite suffering knocks last week, but Micah Richards is likely to miss the match due to knee injury, with Joleon Lescott poised to continue in the back four. Garde will also be without long-term injury victim Jordan Amavi.
Wenger could choose to rotate his side following their exploits in midweek in Greece, but does have limited options due to the club's lengthy injury list.
Aston Villa possible starting lineup:
Guzan; Hutton, Okore, Lescott, Bacuna; Veretout, Sanchez, Gueye; Ayew, Gestede, Sinclair
Arsenal possible starting lineup:
Cech; Bellerin, Mertesacker, Koscielny, Gibbs; Ramsey, Flamini; Campbell, Ozil, Oxlade-Chamberlain; Giroud
Head To Head
The sides last met in the FA Cup final last season when the Gunners eased to a 4-0 triumph at Wembley, which was their third victory over Villa during the 2014-15 campaign.
Over the course of history, Arsenal have edged the duel by winning 80 of the 191 matches between the sides, while Villa have won 66 games, with 45 of the contests ending in draws.
We say: Aston Villa 0-2 Arsenal
Villa showed signs of improvement last week, but they are still vulnerable at the back and lack a threat in the final third. As a result, Arsenal will be able to pick up the three points to continue their good week by maintaining their challenge for the Premier League title.