Scott Sinclair scored a spectacular long-range effort on Tuesday night, helping the Lilywhites to all three points after they had appeared to let a 2-0 lead slip.
Preston surged into a two-goal advantage against the Cherries and, despite conceding late on, they were able to go on to seal their fifth away win of the season - maintaining the best away form in the division, in which they are also top scorers.
That statistic is partly down to the resurgence of Tom Barkhuizen, who after a run of 24 Championship games without a goal, has scored three in his last four games in the competition.
Preston have won their last five matches against Wycombe Wanderers in all competitions, with this their first meeting since January 2018 in the FA Cup, when they secured a 5-1 win.
As for Wycombe, fans will have been pleased that they were one of six EFL clubs in a position to admit fans in midweek, and the joy and relief at the ground was there for all to see.
Alas, it ended in defeat as Nick Powell's header was enough to give the Potters the win, and they are now back on the road where their form has been anything but convincing.
In a run stretching back to December 2019, Wycombe have lost 11 of their last 14 away league games, with only Coventry City earning fewer points on the road than the Chairboys in the Championship this season.
Wycombe are winless in their last 12 competitive matches against Preston since beating them 4-2 in the 1994 fourth-tier playoff final at Wembley.
Preston North End Championship form: LWLWLW
Wycombe Wanderers Championship form: WLDDDL
Preston North End centre-back Patrick Bauer will miss the rest of the season following an Achilles tendon injury.
The 28-year-old was hurt late on in his side's 3-2 win at Bournemouth on Tuesday, having earlier scored their third goal at the Vitality Stadium.
Defender Paul Huntingdon will likely fill in for the injured Bauer.
Preston North End possible starting lineup:
Rudd; Storey, Huntingdon, Davies; Pearson; Sinclair, Barkhuizen, Potts, Johnson; Jakobsen, Maguire
Wycombe Wanderers possible starting lineup:
Allsopp; Grimmer, Stewart, Knight, Jacobson; Wheeler, Adeniran, Bloomfield; McCleary, Akinfenwa, Horgan
We say: Preston North End 2-1 Wycombe Wanderers
Preston have been far from their best at Deepdale this season, but we see them coming out on top against a Wycombe side who have failed to secure a win in their last five matches.