The Saints have managed to put three points between themselves and the bottom three, despite losing 2-1 to Manchester United in new manager Mauricio Pochettino's second game in charge of the club.
Wigan, who have battled relegation in the last few seasons, will aim to begin an unbeaten run this weekend following their 2-2 draw against Stoke City on Tuesday.
Possible starting lineups
Wigan: Al-Habsi; Scharner, Caldwell, Figueroa; Boyce, McArthur, McCarthy, Espinoza, Beausejour; Maloney, Di Santo
Southampton: Boruc; Clyne, Yoshida, Hooiveld, Fox; Schneiderlin, Cork; Puncheon, Rodriguez, Ramirez; Lambert
Sports Mole says: 1-1