Vitesse and Groningen have tasted defeat only once in their last five league games apiece, and are second and sixth respectively in the Eredivisie table as the season enters into its second half.
The home side advanced to the last eight of the KNVB-Beker on Tuesday, narrowly edging out ADO Den Haag in a 2-1 home triumph courtesy of goals from Lois Openda and Matus Bero, before Amar Catic pulled one back for the away side.
Thomas Letsch's men have turned their home ground into a real fortress this term, going unbeaten in eight games in all competitions to date, while dropping points only once in that time.
In Eredivisie home matches, they have conceded the fewest number of goals, and have also picked up the joint-most points alongside Ajax, who have played a game more.
The loan signing of Armando Broja from Chelsea has proven to be fruitful, as the 19-year-old Albanian's six goals have helped propel Vitas to second place, and on course for their highest league finish since 1998.
Groningen were headed for a third home league defeat of the season last Sunday as they trailed Twente by two goals at half time through strikes from Dario Dumic and Thijs van Leeuwen, which came 10 minutes apart.
However, they showed real doggedness and resilience after the interval as they came back to earn a point in a 2-2 draw.
With Feyenoord and AZ - two of the teams ahead of them - set to meet this weekend, Trots van het Noorden have an opportunity to make up ground on those around them in the race for European football.
Vitesse Eredivisie form: DWLWWW
Vitesse form (all competitions): WLWWWW
Groningen Eredivisie form: WWLDWD
Groningen form (all competitions): LWLDWD
Thomas Letsch shuffled the pack for the cup tie earlier in the week, but you can expect him to field his strongest side for this one.
Groningen are not without injury problems of their own as Arjen Robben still remains on the sidelines.
However, he could be back for the closing stages of the season, and it will be fascinating to see how much he still has left in him.
Vitesse possible starting lineup:
Pasveer; Wittek, Rasmussen, Bazoer, Doekhi, Dasa; Bero, Tannane, Bruns; Buitink, Broja
Groningen possible starting lineup:
Padt; Gudmundsson, Van Hintum, Itakura, Dankerlui; Matusiwa, El Messaoudi, Suslov; El Hankouri, Da Cruz, Strand Larsen
We say: Vitesse 2-1 Groningen
Vitesse's fantastic home record coupled with the momentum of three league wins on the bounce simply make them the favourites for this one, but we expect the away side to push them all the way in what should be a tight affair.