Andrezzoli will take charge of his first Rome derby, but is more than familiar with the clash after years on the coaching staff at the Giallorossi.
With three points imperative following last week's defeat at Palermo, the interim coach has insisted that his side must keep their cool to claim victory.
He told reporters in his pre-match press conference: "It is a great privilege for me to be here for the Rome derby and I want to enjoy it all the way. The fact Lazio have won the last three derbies could weigh on us, but we have to focus only on this match.
"It will be decisive to keep our cool, especially as there were so many red cards in recent meetings with Lazio. Obviously winning against Palermo would have allowed us to go into this game with three more points and the confidence that had been building in recent weeks.
"The derby is worth three points, but also so much more than that. We need to use the ability to suffer under pressure and turn that pressure into positive energy."
Roma sit seventh in Serie A ahead of the derby, three points behind their bitter city rivals.