Eibar vs. Alaves (Saturday, 1.00pm)
Three points for Alaves could see them go four points clear of the drop zone in La Liga, while defeat for Eibar would all but relegate the hosts.
We say: Eibar 0-2 Alaves
We would expect Eibar to come out swinging in this tie, given what is at stake, but Alaves are the in-form team here and we think they will be able to put Eibar to the sword.
Elche vs. Atletico (Saturday, 3.15pm)
Following a string of poor results in recent weeks, Atleti's title hopes hang in the balance, with three points this weekend crucial to Diego Simeone's title bid.
We say: Elche 1-2 Atletico Madrid
In typical Atleti manner, it will be a tight game, but we think Simeone's men will eventually come out on top in this tie. Expect archetypal finishes from the likes of Suarez and Marcos Llorente to seal it.
Huesca vs. Real Sociedad (Saturday, 5.30pm)
Three points for fifth-placed La Real could go a long way towards securing European football next season, while a win for Huesca would be a huge scalp in their pursuit of top-flight survival.
We say: Huesca 2-0 Real Sociedad
Huesca have been wont to play in strange cycles this season, with positive spells undermined by long periods of mediocrity. We think Pacheta's men will be up for this one, keeping the dream of the great Huescape alive and kicking - for now anyway.
Real Madrid vs. Osasuna (Saturday, 8.00pm)
We say: Real Madrid 2-0 Osasuna
Madrid will certainly have one eye on next week's trip to Chelsea, but they cannot afford to drop more points in La Liga during a vital stage of the season. Osasuna are capable of making this a tricky match, but we are expecting the hosts to pick up all three points in relatively routine fashion.