Meanwhile, the Toffees will be hopeful that they can progress beyond the third round for the first time since the 2011-12 campaign.
The Royals showed their pedigree in the cup competitions when they progressed to the last four of the FA Cup last season, despite their struggles in the Championship.
However, Steve Clarke's men will be able to take confidence into their League Cup campaign despite their poor performance in the competition last season when they were eliminated in the third round by Derby County.
The Royals have enjoyed a solid start to the campaign in the Championship this season by climbing into the top six in the early stages, managing to shake off their underwhelming 19th-place finish last term.
Clarke's side failed to win any of their first four matches in the second tier, but did beat Colchester United and Portsmouth in the League Cup, which sparked them into life. They went on to win three games on the spin, including a 5-1 win over Ipswich Town at the Madejski Stadium.
The Royals have kept four clean sheets in their 10 matches in all competitions this season, but have managed just one in their last four games, which will be a concern to Clarke heading into the clash against the Toffees.
Recent form: DDWWLW
Recent form (all competitions): DWWWLW
Everton have historically struggled in the League Cup, having never won the competition in their history.
The club have reached the final of cup twice, but those appearances came in 1984 and 1977 and the closest they have come since is a semi-final berth in 2008.
The Toffees' recent record does not make for pleasant reading for their supporters as they have failed to progress beyond round four since they reached the semis seven years ago.
Roberto Martinez will be determined to end his side's poor run of form in the competition after they were forced to battle past Barnsley in the second round, needing extra time to see off the League One outfit at Oakwell.
Everton have been in solid form in the Premier League, losing just once this campaign so far, while they are unbeaten in their last three matches since going down to Manchester City.
The Toffees have shown resilience on their travels this season, with all three of their clean sheets in the top flight coming from their away matches, including their goalless draw with Swansea City at the weekend.
At the other end of the pitch, Martinez will have concerns over his side's inability to find the net as Steven Naismith's hat-trick against Chelsea have been their only goals since their five against the Tykes on August 26.
Recent form: DWLDWD
Recent form (all competitions): WLWDWD
Clarke has hinted that he could make changes to his side from their win over Bristol City on Saturday for the clash with the Toffees.
Bryan Oviedo and Seamus Coleman are expected to miss out due to injury, but Mason Holgate could feature after recovering from a knock. Kevin Mirallas is out of the match as he begins the first game of his suspension.
Reading possible starting lineup:
Bond; Gunter, Cooper, Hector, Obita; Williams, Fernandez, Norwood; Piazon, Blackman, Hurtado
Everton possible starting lineup:
Robles; Browning, Funes Mori, Stones, Galloway; Gibson, Osman; Deulofeu, Barkley, Lennon; Kone
Head To Head
There have only been 10 meetings between the teams over the course of history, and Everton have won six of the contests compared to Reading's three, while one match ended in a stalemate.
We say: Reading 1-2 Everton
Reading have played well in the Championship this season and are in good form at the moment, but so are Everton, who are competing at a higher level. Expect a tight match at the Madejski Stadium, but the Toffees will have enough to edge the contest.