Meanwhile, the visitors will be hoping to maintain their superb form in Eredivisie as they continue to chase Ajax at the top of the table - currently sitting just three points behind the reigning champions.
Waalwijk have endured a mediocre start to the 2020-21 season, having registered just three wins and three draws thus far, with Fred Grim's men in 12th position as they head into Saturday's game.
The home side have also suffered six defeats in their opening 12 matches, including one against Groningen last Saturday, with the only goals of the game coming from the opposing team as Ahmed El Messaoudi and Daniel van Kaam managed to get on the scoresheet.
In fact, Waalwijk have struggled going forward this campaign, having netted just 11 goals since the start of the season, with three of those goals coming in their 3-2 win against VVV-Venlo just two weeks ago.
If they do manage to claim the win this weekend, it could see them climb to ninth spot in the table, overtaking both PEC Zwolle and FC Utrecht.
PSV, on the other hand, will be in high spirits after their 2-1 win over De Graafschap in the KNVB Cup in midweek, progressing to the third round of the competition.
Domestically, they have also had an excellent start to the season, losing just one game thus far - a 2-1 defeat against Vitesse back in October, as they currently occupy second place in the table.
The German coach will also be pleased about his side's positive start to the Europa League this term, with PSV putting in a dominant display against AC Omonia in matchday six of the competition - topping their group and qualifying for the knockout stages.
They last met Waalwijk in September last year, when PSV managed a 3-1 victory against their opponents in the 2019-20 Eredivisie season.
However, it is worth noting that in their previous 10 meetings, PSV have only managed a slightly better record - securing six wins against Waalwijk's four.
RKC Waalwijk Eredivisie form: LWWDLL
PSV Eindhoven Eredivisie form: WDWDWW
PSV Eindhoven form (all competitions): WWWDWW
Waalwijk fans will be pleased to know that they have no injuries or suspensions heading into this game, with Grim currently possessing a full-strength squad.
However, Finn Stokkers is likely to keep his place up front, with the striker managing three league goals thus far.
RKC Waalwijk possible starting lineup:
Lamprou; Bakari, Meulensteen, Touba, Quasten; Van der Venne, Anita, Tahiri; Ngonge, Stokkers, Daneels
PSV Eindhoven possible starting lineup:
Mvogo; Dumfries, Teze, Boscagli, Max; Rosario, Sangare; Gotze, Ihattaren; Gakpo, Malen
We say: RKC Waalwijk 0-2 PSV Eindhoven
Despite their injuries, we predict PSV to gain a comfortable victory away in Waalwijk on Saturday, with Schmidt's men desperate to continue their impressive form. The hosts, meanwhile, have struggled to find the back of the net this season, and we do not see them getting many past PSV at the weekend.